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01000naa a22002652 4500 |
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NLM155374877 |
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DE-627 |
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20231223072008.0 |
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tu |
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231223s2005 xx ||||| 00| ||eng c |
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|a (DE-627)NLM155374877
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|a (NLM)15893691
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Ozdemir, Oner
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Combinational IL-2/IL-15 induction does not further enhance IL-15-induced lymphokine-activated killer cell cytotoxicity against human leukemia/lymphoma cells
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| 264 |
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|c 2005
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 14.07.2005
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|a Date Revised 21.11.2008
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a In vitro comparisons of induction of perforin (PFP), granzyme B (GRB), production of cytokines, and cell-mediated cytotoxicity by interleukin-2 (IL-2), interleukin-15 (IL-15), or combinational IL-2/IL-15-induced lymphokine-activated killer cells were studied in this study. Whereas IL-2-induction was associated with a decrease in cultured cell population over a 7-day period, IL-15 alone or in combination with IL-2 resulted in significant increase including cytotoxic T lymphocytes and subsets of CD56+ lymphocytes, particularly cytokine-induced killer and cytolytic natural killer-T lymphocytes. The overall PFP, GRB, and tumor necrosis factor-alpha expression in different subtypes were also significantly higher with IL-15 alone or in combination with IL-2 induction with resultant superior cytotoxicity compared to IL-2 treatment. There was no significant advantage of addition of IL-2 over IL-15 induction. These results offer further information on the cytotoxic potency of these cytokines and their mechanisms of action implicating potential use of IL-15 as part of cytokine adoptive immunotherapy
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Interleukin-15
|2 NLM
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| 650 |
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|a Interleukin-2
|2 NLM
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| 650 |
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|a Lymphokines
|2 NLM
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|a Membrane Glycoproteins
|2 NLM
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|a Pore Forming Cytotoxic Proteins
|2 NLM
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|a Tumor Necrosis Factor-alpha
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| 650 |
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|a GZMB protein, human
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| 650 |
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|a EC 3.4.21.-
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| 650 |
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|a Granzymes
|2 NLM
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| 650 |
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|a EC 3.4.21.-
|2 NLM
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| 650 |
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|a Serine Endopeptidases
|2 NLM
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| 650 |
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|a EC 3.4.21.-
|2 NLM
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| 700 |
1 |
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|a Savaşan, Süreyya
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 115(2005), 3 vom: 31. Juni, Seite 240-9
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:115
|g year:2005
|g number:3
|g day:31
|g month:06
|g pages:240-9
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