Islet-cell antigen-reactive T cells show different expansion rates and Th1/Th2 differentiation in type 1 diabetic patients and healthy controls

Islet-cell antigen-reactive T cells show different expansion rates and Th1/Th2 differentiation in type 1 diabetic patients and healthy controls

The low frequency of islet-cell antigen-reactive T cells in type 1 diabetes makes their direct measurement difficult. Commonly used in vitro expansion could alter in vivo frequencies and Th1/Th2 differentiation states. Using IFN-gamma/IL-4 double color ELISPOT, we tested longitudinally the reactivit...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 115(2005), 1 vom: 07. Apr., Seite 102-14
1. Verfasser: Ott, Patrick A (VerfasserIn)
Weitere Verfasser: Herzog, Bernhard A, Quast, Stefan, Hofstetter, Harald H, Boehm, Bernhard O, Tary-Lehmann, Magdalena, Durinovic-Bello, Ivana, Berner, Beate R, Lehmann, Paul V
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Autoantigens Isoenzymes Membrane Proteins Peptide Fragments Interleukin-4 207137-56-2 mehr... Interferon-gamma 82115-62-6 Proinsulin 9035-68-1 PTPRN protein, human EC 3.1.3.48 Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases Receptor-Like Protein Tyrosine Phosphatases, Class 8 Glutamate Decarboxylase EC 4.1.1.15 glutamate decarboxylase 2