Angiopoietin-like-4 is a potential angiogenic mediator in arthritis

Our previous studies of gene expression profiling during collagen-induced arthritis (CIA) indicated that the putative angiogenic factor Angptl4 was one of the most highly expressed mRNAs early in disease. To investigate the potential involvement of Angptl4 in CIA pathogenesis, Angptl4 protein levels...

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Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 115(2005), 1 vom: 01. Apr., Seite 93-101
1. Verfasser:	Hermann, L M (VerfasserIn)
Weitere Verfasser:	Pinkerton, M, Jennings, K, Yang, L, Grom, A, Sowders, D, Kersten, S, Witte, D P, Hirsch, R, Thornton, S
Format:	Aufsatz
Sprache:	English
Veröffentlicht:	2005
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Angiopoietin-1 Angiopoietin-Like Protein 4 Angiopoietins Angptl4 protein, mouse Blood Proteins Il1rl1 protein, mouse mehr... Interleukin-1 Receptor-Like 1 Protein Membrane Proteins Platelet Endothelial Cell Adhesion Molecule-1 RNA, Messenger Receptors, Interleukin Vascular Endothelial Growth Factor A Collagen 9007-34-5 Receptor, TIE-2 EC 2.7.10.1

Beschreibung
Zusammenfassung:	Our previous studies of gene expression profiling during collagen-induced arthritis (CIA) indicated that the putative angiogenic factor Angptl4 was one of the most highly expressed mRNAs early in disease. To investigate the potential involvement of Angptl4 in CIA pathogenesis, Angptl4 protein levels were assessed at early stages of disease and its cellular sources were determined. In addition, the functional effects of mouse Angptl4 on endothelial cells were assessed. Angptl4 protein levels were higher in arthritic joints as compared to normal joints. In situ hybridization localized Angptl4 mRNA to stromal fibroblast-like cells within the inflamed synovium. Temporal expression of Angptl4 mRNA during CIA was similar to that of key angiogenic factors, including structurally related angiopoietin 1. Recombinant mouse Angptl4 promoted endothelial cell survival and formation of tubule-like structures. These functional effects of Angptl4, combined with very high expression at early stages of CIA, suggest a role for Angptl4 in angiogenesis in arthritis
Beschreibung:	Date Completed 30.06.2005 Date Revised 03.12.2021 published: Print Citation Status MEDLINE
ISSN:	1521-7035