Structural study of DNA condensation induced by novel phosphorylcholine-based copolymers for gene delivery and relevance to DNA protection

Poly[2-(dimethylamino)ethyl methacrylate-b-2-methacryloyloxyethyl phosphorylcholine] (DMA-MPC) is currently under investigation as a new vector candidate for gene therapy. The DMA block has been previously demonstrated to condense DNA effectively. The MPC block contains a phosphorylcholine (PC) head...

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Bibliographische Detailangaben
Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 21(2005), 8 vom: 12. Apr., Seite 3591-8
1. Verfasser: Chim, Y T A (VerfasserIn)
Weitere Verfasser: Lam, J K W, Ma, Y, Armes, S P, Lewis, A L, Roberts, C J, Stolnik, S, Tendler, S J B, Davies, M C
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Comparative Study Journal Article Research Support, Non-U.S. Gov't Biopolymers Cations Methacrylates poly(2-(dimethylamino)ethyl methacrylate-b-2-methacryloyloxyethyl phosphorylcholine) Phosphorylcholine 107-73-3 DNA mehr... 9007-49-2 Deoxyribonuclease I EC 3.1.21.1