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DE-627 |
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20231223064711.0 |
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231223s2005 xx ||||| 00| ||eng c |
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|a pubmed24n0513.xml
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|a (NLM)15721841
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Cetkovic-Cvrlje, Marina
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Effect of targeted disruption of signal transducer and activator of transcription (Stat)4 and Stat6 genes on the autoimmune diabetes development induced by multiple low doses of streptozotocin
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| 264 |
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|c 2005
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 19.04.2005
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a The MLDS (multiple low doses of streptozotocin) model of diabetes was induced in Stat4(-/-), Stat6(-/-), and double-deficient Stat4(-/-)/6(-/-) mice to examine the role of STAT4/STAT6 deficiency in development of autoimmune diabetes. Cytokine production of T-cells from Stat4(-/-) mice confirmed a predominantly Th2-type immune response. Stat4(-/-) mice exhibited delayed onset and reduced severity of disease compared to wild-type (WT) mice. In contrast, STAT6 deficiency, with a predominant Th1 response, did not influence the kinetics or severity of MLDS-induced autoimmune diabetes. Interestingly, Stat4(-/-)/6(-/-) mice, with a prominent Th1-type response, experienced an accelerated and aggravated course of diabetes after MLDS, implicating a STAT4-independent Th1 response in the immunopathogenesis of MLDS-induced autoimmune diabetes. The sensitivity of islet cells from Stat4(-/-) or Stat4(-/-)/6(-/-) mice to cytokines and STZ was not different from that of islet cells of WT mice. Hence, the observed effects of STAT4 and STAT4/6 deficiency on MLDS-induced autoimmune diabetes are likely due to their effects on T-cell responses
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|a Journal Article
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|a Cytokines
|2 NLM
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| 650 |
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|a DNA-Binding Proteins
|2 NLM
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| 650 |
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|a STAT4 Transcription Factor
|2 NLM
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| 650 |
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|a STAT6 Transcription Factor
|2 NLM
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| 650 |
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|a Stat4 protein, mouse
|2 NLM
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| 650 |
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|a Stat6 protein, mouse
|2 NLM
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| 650 |
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|a Trans-Activators
|2 NLM
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| 650 |
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|a Streptozocin
|2 NLM
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| 650 |
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|a 5W494URQ81
|2 NLM
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| 700 |
1 |
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|a Uckun, Fatih M
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 114(2005), 3 vom: 25. März, Seite 299-306
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:114
|g year:2005
|g number:3
|g day:25
|g month:03
|g pages:299-306
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|a AR
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| 952 |
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|d 114
|j 2005
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|h 299-306
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