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DE-627 |
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20250206052329.0 |
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231223s2005 xx ||||| 00| ||chi c |
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|a pubmed25n0512.xml
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|a (DE-627)NLM153562633
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|a (NLM)15698495
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Weng, Li-xin
|e verfasserin
|4 aut
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| 245 |
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|a Protective effects of acidic fibroblast growth factor on intestinal ischemia/reperfusion in rats
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| 264 |
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|c 2005
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 06.10.2009
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| 500 |
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To observe the change in hepatic and renal functions, change in the plasma D-lactate level, and the expression of proliferating cell nuclear antigen (PCNA) after intestinal I/R injury, so as to explore the effects of reconstructive human acid fibroblast growth factor(aFGF) on intestinal I/R injury in rats
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|a METHODS: One hundred and twenty-six Wistar rats were divided into sham-operated, ischemia (45 minutes) plus reperfusion, reconstructive human aFGF treatment (2, 4, 8 microg aFGF) and wild type aFGF(2, 6, 12, and 24 hours, respectively) groups. Hepatic and renal functions and the levels of plasma D-lactate were determined and the expression of PCNA was assessed
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|a RESULTS: Compared with all other groups, bowel barrier function and hepatic and renal functions showed most marked deterioration in sham-operated group. The damages were less marked in reconstructive human aFGF group compared with other groups 24 hours after ischemia/reperfusion of the intestine, and the protective effect was best shown when 4 microg of aFGF was given. The trend of expression of PCNA was similar to that of changes in D-lactate level
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|a CONCLUSION: Wild type reconstructive human aFGF treatment significantly improves the outcome of ischemia/reperfusion injury to the intestine, and the effect is dose-dependent
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|a English Abstract
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Proliferating Cell Nuclear Antigen
|2 NLM
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| 650 |
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|a Fibroblast Growth Factor 1
|2 NLM
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| 650 |
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|a 104781-85-3
|2 NLM
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| 650 |
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|a Lactic Acid
|2 NLM
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| 650 |
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7 |
|a 33X04XA5AT
|2 NLM
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| 700 |
1 |
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|a Fu, Xiao-bing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xiu-xia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Tong-zhu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Shu-yun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Jun-you
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 17(2005), 2 vom: 08. Feb., Seite 98-101
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:17
|g year:2005
|g number:2
|g day:08
|g month:02
|g pages:98-101
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 17
|j 2005
|e 2
|b 08
|c 02
|h 98-101
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