Acellular porcine dermal matrix produced with different methods and an experimental study on its transplantation to skin wound

OBJECTIVE: To observed the effect of healing quality of composite skin grafting consisting of acellular porcine dermal matrix combined with autologous split-thickness skin graft

Bibliographische Detailangaben
Veröffentlicht in:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. - 1998. - 17(2005), 2 vom: 08. Feb., Seite 92-4
1. Verfasser: Ma, Zhong-feng (VerfasserIn)
Weitere Verfasser: Chai, Jia-ke, Yang, Hong-ming, Liu, Qiang, Xu, Ming-huo, Yin, Hui-nan
Format: Aufsatz
Sprache:Chinese
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Schlagworte:English Abstract Journal Article Research Support, Non-U.S. Gov't
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245 1 0 |a Acellular porcine dermal matrix produced with different methods and an experimental study on its transplantation to skin wound 
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500 |a Date Completed 06.10.2009 
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500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a OBJECTIVE: To observed the effect of healing quality of composite skin grafting consisting of acellular porcine dermal matrix combined with autologous split-thickness skin graft 
520 |a METHODS: Porcine skin was treated with dispase II/triton X-100 or hyperosmotic saline/sodium-dodecyl-sulfate (SDS) respectively, and acellular porcine dermal matrix I (APDMI) and APDM II were obtained. Sixty-three Sprague-Dawley rats with full-thickness skin defects on the back were separately covered with APDMT + split-thickness autologous skin, or APDM II + split-thickness autologous skin. The quality of wound healing was observed, the rates of survival and contraction of the grafts were calculated, the tissue samples were harvested for histological examination, and compared with that of autologous split-thickness skin graft 
520 |a RESULTS: The wound healing quality of composite skin I, and II was good. There was no significant difference in the rate of survival and contraction of the grafts between the two composite skin grafting groups. It was indicated by histological examination intact basal membrane. There was no significant difference in the survival rate between composite skin grafting groups and autologous split-thickness skin at the 6 th week after operation, but the contraction rates of the grafts in the composite skin groups were lower 
520 |a CONCLUSION: Full-thickness skin defect can be healed by covering with acellular porcine dermal matrix produced by two methods combined with split-thickness autograft, and it can help improve the quality of wound healing 
650 4 |a English Abstract 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
700 1 |a Chai, Jia-ke  |e verfasserin  |4 aut 
700 1 |a Yang, Hong-ming  |e verfasserin  |4 aut 
700 1 |a Liu, Qiang  |e verfasserin  |4 aut 
700 1 |a Xu, Ming-huo  |e verfasserin  |4 aut 
700 1 |a Yin, Hui-nan  |e verfasserin  |4 aut 
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