|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM153562579 |
| 003 |
DE-627 |
| 005 |
20250206052328.0 |
| 007 |
tu |
| 008 |
231223s2005 xx ||||| 00| ||chi c |
| 028 |
5 |
2 |
|a pubmed25n0512.xml
|
| 035 |
|
|
|a (DE-627)NLM153562579
|
| 035 |
|
|
|a (NLM)15698487
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a chi
|
| 100 |
1 |
|
|a Nie, Fang-fei
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Expression of thymosin beta 4 mRNA expression in keloid tissues and fibroblasts cultured from keloid and its significance
|
| 264 |
|
1 |
|c 2005
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
|
| 338 |
|
|
|a Band
|b nc
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 06.10.2009
|
| 500 |
|
|
|a Date Revised 24.11.2016
|
| 500 |
|
|
|a published: Print
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a OBJECTIVE: To investigate the relations between thymosin beta 4 and pathologic scars by comparing the mRNA levels of thymosin beta 4 in keloid, hypertrophic scar and normal skin
|
| 520 |
|
|
|a METHODS: The primary fibroblasts from the patients of keloid (KFB), hypertrophic scar (HFB) and normal skin (NFB, n=7) were cultured in vitro with tissue culture system. Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) assay was used to assess the thymosin beta 4 mRNA levels in the tissues and fibroblasts obtained from the patients of three groups
|
| 520 |
|
|
|a RESULTS: The mRNA levels of thymosin beta 4 in the keloid tissues were lower than those in the tissues of hypertrophic scar and normal skin(both, P<0.01). The thymosin beta 4 mRNA level in keloid group was lower by 66.98% than hypertrophic scar, and 62.48% than normal skin. In addition, the same significant change was found in the cultured KFB compared with HFB group(the mean value was lower by 27.13%), but no difference was found between KFB and NFB
|
| 520 |
|
|
|a CONCLUSION: Expression of thymosin beta 4 is closely related with keloid. The inadequate expression of thymosin beta 4 may be one of the key factors for keloid formation
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a RNA, Messenger
|2 NLM
|
| 650 |
|
7 |
|a thymosin beta(4)
|2 NLM
|
| 650 |
|
7 |
|a 549LM7U24W
|2 NLM
|
| 650 |
|
7 |
|a Thymosin
|2 NLM
|
| 650 |
|
7 |
|a 61512-21-8
|2 NLM
|
| 700 |
1 |
|
|a Wu, Jiang-qun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Qin, Ze-lian
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 17(2005), 2 vom: 08. Feb., Seite 80-3
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
|
| 773 |
1 |
8 |
|g volume:17
|g year:2005
|g number:2
|g day:08
|g month:02
|g pages:80-3
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 17
|j 2005
|e 2
|b 08
|c 02
|h 80-3
|