The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules

The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules

Low-dose methotrexate (MTX) is an established and highly effective treatment for severe psoriasis and rheumatoid arthritis; however, its mechanism of action remains unclear. We investigated the effects of low-dose MTX on antigen-stimulated peripheral blood mononuclear cells and explored through whic...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 114(2005), 2 vom: 10. Feb., Seite 154-63
1. Verfasser: Johnston, Andrew (VerfasserIn)
Weitere Verfasser: Gudjonsson, Johann Eli, Sigmundsdottir, Hekla, Ludviksson, Björn Runar, Valdimarsson, Helgi
Format: Aufsatz
Sprache:English
Veröffentlicht: 2005
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Anti-Inflammatory Agents Antigens, Bacterial Antigens, Differentiation, T-Lymphocyte Antigens, Neoplasm CTAGE1 protein, human Cell Adhesion Molecules Integrins Membrane Glycoproteins mehr... P-selectin ligand protein RNA, Messenger Receptors, Interleukin-2 Intercellular Adhesion Molecule-1 126547-89-5 RNA 63231-63-0 Fucosyltransferases EC 2.4.1.- galactoside 3-fucosyltransferase EC 2.4.1.152 Adenosine K72T3FS567 Leucovorin Q573I9DVLP Methotrexate YL5FZ2Y5U1