15d-PGJ2 : the anti-inflammatory prostaglandin?
15-Deoxy-Delta-12,14-prostaglandin J2 (15d-PGJ2) is the most recently discovered prostaglandin. This cyclopentanone, the dehydration end product of PGD2, differs from other prostaglandins in several respects. There is no specific prostaglandin synthase (PGS) leading to 15d-PGJ2 production and no spe...
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 114(2005), 2 vom: 10. Feb., Seite 100-9 |
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| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2005
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.) |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Review 15-deoxyprostaglandin J2 NF-kappa B PPAR gamma Prostaglandin-Endoperoxide Synthases EC 1.14.99.1 Prostaglandin D2 RXY07S6CZ2 |
| Zusammenfassung: | 15-Deoxy-Delta-12,14-prostaglandin J2 (15d-PGJ2) is the most recently discovered prostaglandin. This cyclopentanone, the dehydration end product of PGD2, differs from other prostaglandins in several respects. There is no specific prostaglandin synthase (PGS) leading to 15d-PGJ2 production and no specific 15d-PGJ2 receptor has been identified to date. Instead, 15d-PGJ2 has been shown to act via PGD2 receptors (DP1 and DP2) and through interaction with intracellular targets. In particular, 15d-PGJ2 is recognized as the endogenous ligand for the intranuclear receptor PPARgamma. This property is responsible for many of the 15d-PGJ2 anti-inflammatory functions. In this review, we summarize the current understanding of 15d-PGJ2 synthesis, biology and main effects both in molecular physiology and pathological states |
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| Beschreibung: | Date Completed 08.03.2005 Date Revised 08.01.2021 published: Print Citation Status MEDLINE |
| ISSN: | 1521-7035 |