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01000naa a22002652 4500 |
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NLM152601260 |
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DE-627 |
| 005 |
20231223062344.0 |
| 007 |
tu |
| 008 |
231223s2005 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed24n0509.xml
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| 035 |
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|a (DE-627)NLM152601260
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| 035 |
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|a (NLM)15596412
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| 040 |
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Bonfield, Tracey L
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Elevated monocyte chemotactic proteins 1, 2, and 3 in pulmonary alveolar proteinosis are associated with chemokine receptor suppression
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| 264 |
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1 |
|c 2005
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 15.02.2005
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| 500 |
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|a Date Revised 15.11.2007
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Pulmonary alveolar proteinosis (PAP) is a rare autoimmune lung disease characterized by abnormal surfactant accumulation within alveolar macrophages, and circulating auto-antibodies against granulocyte-macrophage colony stimulating factor (GM-CSF) resulting in functional GM-CSF deficiency. Monocyte/macrophage chemotactic protein-1 (MCP-1) is elevated in PAP, suggesting association with the pathophysiology. Because PAP has been associated with inflammatory pulmonary changes, we hypothesized that other MCP family chemokines would be present and that Chemokine Chemotaxis Receptor 2 (CCR2) would be elevated on PAP mononuclear cells. Here we show for the first time that MCP-2 and MCP-3, like MCP-1, are highly elevated in PAP. We also confirm that PAP alveolar macrophages and not epithelial cells produce MCP-1, and that MCP-1 from PAP lung has functional chemoattractant activity. Surprisingly, CCR2 expression is diminished in PAP lymphocytes and alveolar macrophages compared to controls. Further, MCP-1 from PAP lung suppresses CCR2 expression in vitro, suggesting that in PAP, MCP-1 participates in an autocrine regulatory network in vivo
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| 650 |
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4 |
|a Journal Article
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| 650 |
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7 |
|a CCL7 protein, human
|2 NLM
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| 650 |
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7 |
|a CCL8 protein, human
|2 NLM
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| 650 |
|
7 |
|a CCR2 protein, human
|2 NLM
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| 650 |
|
7 |
|a Chemokine CCL2
|2 NLM
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| 650 |
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7 |
|a Chemokine CCL7
|2 NLM
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| 650 |
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7 |
|a Chemokine CCL8
|2 NLM
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| 650 |
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7 |
|a Chemokines
|2 NLM
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| 650 |
|
7 |
|a Cytokines
|2 NLM
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| 650 |
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7 |
|a Monocyte Chemoattractant Proteins
|2 NLM
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| 650 |
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7 |
|a Receptors, CCR2
|2 NLM
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| 650 |
|
7 |
|a Receptors, Chemokine
|2 NLM
|
| 700 |
1 |
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|a John, Nejimol
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Malur, Anagha
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Barna, Barbara P
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Culver, Daniel A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kavuru, Mani S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Thomassen, Mary Jane
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 114(2005), 1 vom: 10. Jan., Seite 79-85
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:114
|g year:2005
|g number:1
|g day:10
|g month:01
|g pages:79-85
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| 912 |
|
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
|
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|a GBV_NLM
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| 912 |
|
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|a GBV_ILN_11
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| 912 |
|
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|a GBV_ILN_24
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| 912 |
|
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|a GBV_ILN_350
|
| 951 |
|
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|a AR
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| 952 |
|
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|d 114
|j 2005
|e 1
|b 10
|c 01
|h 79-85
|