Nontoxic block copolymer nanospheres : design and characterization
Biodegradable polymers capable of self-assembly into hollow nanospheres of less than 100 nm have significant potential for biotechnology applications such as drug delivery and gene therapy. Here we describe the synthesis of a novel ABA-type triblock copolymer made from a hydrophobic tyrosine-derived...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 20(2004), 26 vom: 21. Dez., Seite 11721-5 |
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| Weitere Verfasser: | , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2004
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Polyethylene Glycols 3WJQ0SDW1A |
| Zusammenfassung: | Biodegradable polymers capable of self-assembly into hollow nanospheres of less than 100 nm have significant potential for biotechnology applications such as drug delivery and gene therapy. Here we describe the synthesis of a novel ABA-type triblock copolymer made from a hydrophobic tyrosine-derived core and two hydrophilic poly(ethylene glycol) end groups (poly(ethylene glycol)-block-oligo(desaminotyrosyltyrosine octyl ester suberate)-block-poly(ethylene glycol)). We describe the self-assembly of this triblock copolymer and characterize its particles as 100 nm size vesicular nanospheres. The vesicular nature of these particles was determined by light scattering and electron microscopy. The nanospheres did not exhibit any short-term cytotoxicity toward UMR-106 cells at a concentration up to 2 mg/mL |
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| Beschreibung: | Date Completed 03.02.2006 Date Revised 01.12.2018 published: Print Citation Status MEDLINE |
| ISSN: | 1520-5827 |