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|e rakwb
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|a eng
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| 100 |
1 |
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|a Chang, Cheng-Hung
|e verfasserin
|4 aut
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| 245 |
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|a Alkanethiolate self-assembled monolayers as functional spacers to resist protein adsorption upon Au-coated nerve microelectrode
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|c 2004
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|2 rdacarrier
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|a Date Completed 03.02.2006
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|a Date Revised 15.11.2006
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|a published: Print
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|a Citation Status MEDLINE
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|a Alkanethiolate self-assembled monolayers (SAMs) of varied chain lengths were adsorbed upon Au-coated nerve microelectrodes and employed as protein-resistant spacers. The microelectrode spiraled as a cuff type can be used for restoring motor function via electrical stimulation on the peripheral nerve system; however, an increase of electrode impedance might occur during implantation. In this work, a thin-film SAMs treatment upon Au/polyimide (PI) surface of the microelectrode provided a hydrophobic characteristic, which retarded protein adsorption at the initial stage and subsequent pileup (or thickening) process. The protein-resistant effect exhibited comparable SAMs of different chain lengths adsorbed upon Au/PI surfaces. The increase of electrode impedance as a function of protein deposition time was mainly correlated with the addition of reactance that was associated with the pileup thickness of the deposited protein. Particularly, the SAMs-modified surface was capable to detach a significant portion of the accumulated protein from the protein-deposited SAMs/Au/PI, whereas the protein-deposited layers exhibited firm adhesion upon Au/PI surface. It is therefore very promising to apply thin-film SAMs adsorbed upon Au-coated surface for bioinvasive devices that have the need of functional electrical stimulations or sensing nerve signals during chronic implantation
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Alkanes
|2 NLM
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|a Blood Proteins
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|a Sulfhydryl Compounds
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|a Gold
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|a 7440-57-5
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| 700 |
1 |
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|a Liao, Jiunn-Der
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|a Chen, Jia-Jin Jason
|e verfasserin
|4 aut
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| 700 |
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|a Ju, Ming-Shaung
|e verfasserin
|4 aut
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| 700 |
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|a Lin, Chou-Ching K
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 20(2004), 26 vom: 21. Dez., Seite 11656-63
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|x 1520-5827
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|g volume:20
|g year:2004
|g number:26
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|g month:12
|g pages:11656-63
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