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NLM151775192 |
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DE-627 |
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20250205232951.0 |
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tu |
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231223s2004 xx ||||| 00| ||eng c |
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|a pubmed25n0506.xml
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|a (DE-627)NLM151775192
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|a (NLM)15507395
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Jansen, Christine A
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Characterization of virus-specific CD8(+) effector T cells in the course of HIV-1 infection
|b longitudinal analyses in slow and rapid progressors
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| 264 |
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1 |
|c 2004
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 15.12.2004
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| 500 |
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|a Date Revised 16.11.2017
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Studies in humans have provided evidence that CD8(+) T cells exhibit distinct phenotypical and functional properties dependent on virus specificity. It is not known how these T-cell phenotypes develop over the course of infection. Dynamics and properties of T cells specific for human immunodeficiency virus (HIV), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) in HIV infection were investigated in relation to viral load. In rapid progressors, HIV-specific CD8(+) T cells were less differentiated early in infection and did not develop a more differentiated phenotype. In slow progressors, perforin expression of HIV-specific CD8(+) T cells slightly increased over time. HIV and EBV loads were detectable in all individuals, while CMV load could not be detected. Thus, in individuals with progressive HIV infection, HIV-specific T cells are less differentiated already early in infection. This apparent block in differentiation may be partly caused by chronic viremia or lack of CD4(+) T-cell help
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Membrane Glycoproteins
|2 NLM
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| 650 |
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7 |
|a Pore Forming Cytotoxic Proteins
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor Receptor Superfamily, Member 7
|2 NLM
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| 650 |
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7 |
|a Perforin
|2 NLM
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| 650 |
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7 |
|a 126465-35-8
|2 NLM
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| 650 |
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7 |
|a GZMB protein, human
|2 NLM
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| 650 |
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7 |
|a EC 3.4.21.-
|2 NLM
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| 650 |
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7 |
|a Granzymes
|2 NLM
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| 650 |
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7 |
|a EC 3.4.21.-
|2 NLM
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| 650 |
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7 |
|a Serine Endopeptidases
|2 NLM
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| 650 |
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7 |
|a EC 3.4.21.-
|2 NLM
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| 700 |
1 |
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|a Piriou, Erwan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bronke, Corine
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vingerhoed, José
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kostense, Stefan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a van Baarle, Debbie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Miedema, Frank
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 113(2004), 3 vom: 12. Dez., Seite 299-309
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
8 |
|g volume:113
|g year:2004
|g number:3
|g day:12
|g month:12
|g pages:299-309
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 113
|j 2004
|e 3
|b 12
|c 12
|h 299-309
|