BAY 50-4798, a novel, high-affinity receptor-specific recombinant interleukin-2 analog, induces dose-dependent increases in CD25 expression and proliferation among unstimulated, human peripheral blood mononuclear cells in vitro

BAY 50-4798, a novel, high-affinity receptor-specific recombinant interleukin-2 analog, induces dose-dependent increases in CD25 expression and proliferation among unstimulated, human peripheral blood mononuclear cells in vitro

Interleukin-2 administration induces CD4 T cell expansion in HIV-infected patients, however, toxicity can limit dosing. BAY 50-4798 is a recombinant IL-2 analog with >1000-fold specificity for the high-affinity IL-2 receptor. The effects of this compound on unstimulated human PBMC were evaluated....

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 113(2004), 3 vom: 12. Dez., Seite 248-55
1. Verfasser: Matthews, Lynn (VerfasserIn)
Weitere Verfasser: Chapman, Sherita, Ramchandani, Meena S, Lane, H Clifford, Davey, Richard T Jr, Sereti, Irini
Format: Aufsatz
Sprache:English
Veröffentlicht: 2004
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Interleukin-2 Ki-67 Antigen Receptors, Interleukin-2 Recombinant Proteins aldesleukin M89N0Q7EQR