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DE-627 |
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20231223060648.0 |
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231223s2004 xx ||||| 00| ||eng c |
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|a pubmed24n0506.xml
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|a (DE-627)NLM151775109
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|a (NLM)15507387
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Salzer, Ulrich
|e verfasserin
|4 aut
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| 245 |
1 |
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|a ICOS deficiency in patients with common variable immunodeficiency
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| 264 |
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|c 2004
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 15.12.2004
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|a Date Revised 17.11.2011
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|a published: Print
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|a Citation Status MEDLINE
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|a Common variable immunodeficiency (CVID) is the most frequent clinically significant primary antibody deficiency in man, predisposing to recurrent bacterial infections. Recently, we showed that the homozygous loss of the inducible costimulator (ICOS) on activated T cells may result in an adult onset form of CVID with autosomal recessive inheritance (AR-CVID). We screened 181 sporadic CVID patients and 13 CVID patients from nine families with AR-CVID for mutations in ICOS by genomic DNA sequencing. In the AR-CVID families, the genomic integrity of the ligand for ICOS (ICOS-L) was also evaluated. In two of the nine AR-CVID families, we identified five individuals with ICOS deficiency, carrying the identical large genomic deletion of ICOS as previously described. In the remaining seven AR-CVID families, we subsequently sequenced the coding region of the ICOS ligand but found no mutations. The incidence of ICOS deficiency among patients with CVID is less than 5%. Worldwide, there are now a total of nine patients diagnosed with ICOS deficiency most likely due to a common founder. ICOS-L deficiency could not be identified in families with AR-CVID
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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7 |
|a Antigens, Differentiation, T-Lymphocyte
|2 NLM
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| 650 |
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7 |
|a ICOS protein, human
|2 NLM
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| 650 |
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7 |
|a Immunoglobulins
|2 NLM
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| 650 |
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7 |
|a Inducible T-Cell Co-Stimulator Protein
|2 NLM
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1 |
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|a Maul-Pavicic, Andrea
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cunningham-Rundles, Charlotte
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Urschel, Simon
|e verfasserin
|4 aut
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| 700 |
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|a Belohradsky, Bernd H
|e verfasserin
|4 aut
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| 700 |
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|a Litzman, Jiri
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Holm, Are
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Franco, José Luis
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Plebani, Alessandro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hammarstrom, Lennart
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Skrabl, Andrea
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schwinger, Wolfgang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Grimbacher, Bodo
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 113(2004), 3 vom: 12. Dez., Seite 234-40
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:113
|g year:2004
|g number:3
|g day:12
|g month:12
|g pages:234-40
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 113
|j 2004
|e 3
|b 12
|c 12
|h 234-40
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