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231223s2004 xx ||||| 00| ||chi c |
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|a pubmed25n0505.xml
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|a (DE-627)NLM151349142
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|a (NLM)15461837
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a chi
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| 100 |
1 |
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|a Yang, Yi
|e verfasserin
|4 aut
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|a Effect of sustained inflation on inflammatory response of extra pulmonary organs in acute respiratory distress syndrome in rabbit
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|c 2004
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 08.09.2009
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|a Date Revised 08.12.2020
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To evaluate the influence of sustained inflation (SI) on inflammatory response of extra pulmonary organs in acute respiratory distress syndrome (ARDS) in rabbit
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|a METHODS: The ARDS rabbit model were replicated by saline alveoli-lavage. The rabbits were randomly divided into four groups: 1. normal group; 2. ARDS group; 3. low-volume(V(T)) + best end-expiratory pressure group (LVBP): V(T) 6 ml/kg, PEEP 2 cm H(2)O(1 cm H(2)O=0.098 kPa) greater than the pressure of lower inflection point in pressure-volume curve (Pinf); 4. SI group: same settings as LVBP group plus SI performed every hour. After 4 hours of ventilation, liver and intestine homogenates were prepared to assay tumor necrosis factor (TNF)-alpha and interleukin(IL)-10 levels by enzyme-linked immunoadsorbent assay and their mRNA expression by reverse transcription-polymerase chain reaction. Myeloperoxidase (MPO) and malondialdehyde (MDA) were assessed at the same time
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|a RESULTS: In SI group, TNF-alpha mRNA expression in the liver and intestine tissues (24.82+/-7.88 and 25.06+/-10.57) were decreased significantly compared with ARDS (36.88+/-6.83 and 36.48+/-8.23) and LVBP groups (42.34+/-8.55 and 37.59+/-10.63, all P<0.05). The expression of IL-10 mRNA in the liver and intestine of rabbits in SI group (17.31+/-5.72 and 10.90+/-3.30) was lower than that of ARDS (24.64+/-3.85 and 24.31+/-7.69) and LVBP group (25.03+/-9.38 and 21.83+/-7.34, all P<0.05) significantly. In SI group, the levels of TNF-alpha and IL-10 in liver and intestine tissue were similar to that of the other groups. The contents of MPO and MDA had no difference compared with the other groups too
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|a CONCLUSION: SI can down-regulate inflammatory mediator expression of extra-pulmonary organs in rabbits with ARDS, and it may inhibit the inflammatory response in extra pulmonary organs
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Inflammation Mediators
|2 NLM
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|a RNA, Messenger
|2 NLM
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| 650 |
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|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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|a Interleukin-10
|2 NLM
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| 650 |
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|a 130068-27-8
|2 NLM
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| 700 |
1 |
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|a Qiu, Hai-Bo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yan, Yan-Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Hong-Yang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Shao-Xia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Rui-Qiang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 16(2004), 10 vom: 04. Okt., Seite 603-7
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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|g volume:16
|g year:2004
|g number:10
|g day:04
|g month:10
|g pages:603-7
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