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01000caa a22002652 4500 |
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NLM151349118 |
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DE-627 |
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20250205220055.0 |
| 007 |
tu |
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231223s2004 xx ||||| 00| ||chi c |
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|a pubmed25n0505.xml
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|a (DE-627)NLM151349118
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| 035 |
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|a (NLM)15461833
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Liu, Hui
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a High mobility group box-1 protein activates Janus kinase-signal transducer and activator of transcription pathway in rat peritoneal macrophages
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| 264 |
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1 |
|c 2004
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 08.09.2009
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| 500 |
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|a Date Revised 15.11.2012
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To investigate the potential signal transduction mechanism in high mobility group box-1 protein (HMGB1)-induced inflammatory response in rat peritoneal macrophages
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| 520 |
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|a METHODS: Peritoneal macrophages obtained from male Wistar rats were incubated for 3 days before they were stimulated by HMGB1 (10 microg/ml). At various time points after HMGB1 stimulation, macrophages were denatured directly in cell culture flasks to detect activation of Janus kinase-2 (JAK2), signal transducer and activator of transcription-1 (STAT1) and STAT3 by immunoprecipitation, Western blotting and electrophoretic mobility shift assay, respectively
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| 520 |
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|a RESULTS: HMGB1 stimulation could activate STAT1 and STAT3 in peritoneal macrophages in 2 hours, among them the activation of STAT3 appeared to be the quickest, peaking as early as 10 minutes after stimulation. But no marked change in JAK2 activity was observed within 2 hours following HMGB1 stimulation
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| 520 |
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|a CONCLUSION: These data suggest that Janus kinase-signal transducer and activator of transcription pathway might be involved in regulation of HMGB1-induced inflammatory response in peritoneal macrophages
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| 650 |
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4 |
|a English Abstract
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a HMGB1 Protein
|2 NLM
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| 650 |
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7 |
|a STAT1 Transcription Factor
|2 NLM
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| 650 |
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7 |
|a STAT3 Transcription Factor
|2 NLM
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| 650 |
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7 |
|a Stat1 protein, rat
|2 NLM
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| 650 |
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7 |
|a Stat3 protein, rat
|2 NLM
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| 650 |
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7 |
|a Jak2 protein, rat
|2 NLM
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| 650 |
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7 |
|a EC 2.7.10.2
|2 NLM
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| 650 |
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7 |
|a Janus Kinase 2
|2 NLM
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| 650 |
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7 |
|a EC 2.7.10.2
|2 NLM
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| 700 |
1 |
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|a Yao, Yong-Ming
|e verfasserin
|4 aut
|
| 700 |
1 |
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|a Dong, Yue-Qing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sheng, Zhi-Yong
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 16(2004), 10 vom: 04. Okt., Seite 592-5
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:16
|g year:2004
|g number:10
|g day:04
|g month:10
|g pages:592-5
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 16
|j 2004
|e 10
|b 04
|c 10
|h 592-5
|