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01000caa a22002652 4500 |
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NLM151349096 |
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DE-627 |
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20250205220055.0 |
| 007 |
tu |
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231223s2004 xx ||||| 00| ||chi c |
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2 |
|a pubmed25n0505.xml
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|a (DE-627)NLM151349096
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|a (NLM)15461830
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Zhang, Qing
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Studies on the expression of mRNA of anti- and pro-inflammatory cytokines in acute lung injury induced by lipopolysaccharide in rat
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| 264 |
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1 |
|c 2004
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 08.09.2009
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| 500 |
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|a Date Revised 05.10.2004
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To study the role of pro-inflammatory cytokines including tumor necrosis factor-alpha(TNF-alpha), interleukin-1beta(IL-1beta), IL-6, and anti-inflammatory cytokines including IL-4, IL-10, and IL-13 in acute lung injury(ALI)
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| 520 |
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|a METHODS: Reverse transcription-polymerase chain reaction(RT-PCR) were used to assess the expressions of mRNA of TNF-alpha, IL-1beta, IL-6, IL-4, IL-10 and IL-13 in the lung tissue after lipopolysaccharide challenge
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| 520 |
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|a RESULTS: The expression of TNF-alpha mRNA was seen to peak at 1 hour and IL-6 mRNA at 4 hours in lung tissue after the challenge. The highest expression of mRNA of other cytokines, such as IL-1beta, IL-4, IL-10 and IL-13 in lung tissue appeared 2 hours after LPS-induced lung injury
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| 520 |
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|a CONCLUSION: TNF-alpha is an early presenting cytokine in ALI, and IL-6 may play an important role in delayed development of ALI. The over-expression of anti-inflammatory cytokines IL-4, IL-10 and IL-13 may act as promoters rather than protectors in amplification of inflammatory process
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| 650 |
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4 |
|a English Abstract
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Interleukin-6
|2 NLM
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| 650 |
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7 |
|a Lipopolysaccharides
|2 NLM
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| 650 |
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7 |
|a RNA, Messenger
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 700 |
1 |
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|a Li, Qi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mao, Bao-Ling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qian, Gui-Sheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Jian-Cheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Zheng-Tang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 16(2004), 10 vom: 04. Okt., Seite 585-8
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:16
|g year:2004
|g number:10
|g day:04
|g month:10
|g pages:585-8
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 16
|j 2004
|e 10
|b 04
|c 10
|h 585-8
|