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231223s2004 xx ||||| 00| ||eng c |
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|a pubmed24n0505.xml
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|a (DE-627)NLM151346194
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|a (NLM)15461519
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Harvey, Richard D
|e verfasserin
|4 aut
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| 245 |
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|a Effect of cholesterol and phospholipid on the behavior of dialkyl polyoxyethylene ether surfactant (2C18E12) monolayers and bilayers
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|c 2004
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 25.04.2006
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|a Date Revised 30.11.2018
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|a published: Print
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|a Citation Status MEDLINE
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|a Copyright 2004 American Chemical Society
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|a Surface pressure-area isotherm, neutron specular reflection, and small-angle neutron scattering studies have been carried out to determine the effects of added cholesterol and distearoylphosphatidylcholine (DSPC), on the molecular structures of monolayers and vesicles containing the dialkyl polyoxyethylene ether surfactant, 1,2-di-O-octadecyl-rac-glyceryl-3-(alpha-dodecaethylene glycol) (2C18E12). Previous neutron reflectivity studies on 2C18E12 monolayers at the air/water interface have shown them to possess a thickness of approximately 24 angstoms and highly disordered structure with significant intermixing of the polymer headgroups and alkyl chains. SANS studies of 2C18E12 vesicles gave a bilayer thickness of approximately 51 angstroms. Addition of cholesterol to 2C18E12 monolayers (1:1 molar ratio), produced a marked condensing effect coupled with an increased the layer thickness of approximately 7 angstroms, and in vesicles, increased bilayer thickness by approximately 16 angstroms. Monolayers consisting of 2C18E12:DSPC:cholesterol (1:1:2 molar ratio), showed a layer thickness of approximately 31 angstroms, whereas in vesicles, three-component bilayer was found to be only approximately 9 angstroms thicker than those possessed by vesicles composed solely of 2C18E12. Mixing between the molecules in three-component monolayers was shown to be ideal through analysis of the neutron reflectivity data. These findings are discussed in relation to increased ordering and decreased headgroup/hydrophobe intermixing within both monolayers and vesicle bilayers containing 2C18E12. The inferred increase in molecular order within vesicles composed of 2C18E12 with additional cholesterol and phospholipid is used as a model for explaining theoretical differences in bilayer permeability
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a 1,2-di-O-octadecylglyceryl-3-(omega-methoxydodecaethylene glycol)
|2 NLM
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|a Ethers
|2 NLM
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|a Membranes, Artificial
|2 NLM
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|a Phospholipids
|2 NLM
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|a Surface-Active Agents
|2 NLM
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| 650 |
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|a Triglycerides
|2 NLM
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| 650 |
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|a Polyethylene Glycols
|2 NLM
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| 650 |
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|a 3WJQ0SDW1A
|2 NLM
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| 650 |
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|a Cholesterol
|2 NLM
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| 650 |
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|a 97C5T2UQ7J
|2 NLM
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| 700 |
1 |
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|a Heenan, Richard K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Barlow, David J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lawrence, M Jayne
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 20(2004), 21 vom: 12. Okt., Seite 9282-90
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:20
|g year:2004
|g number:21
|g day:12
|g month:10
|g pages:9282-90
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_22
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|a GBV_ILN_350
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|a GBV_ILN_721
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|a AR
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|d 20
|j 2004
|e 21
|b 12
|c 10
|h 9282-90
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