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231223s2004 xx ||||| 00| ||eng c |
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|a (NLM)15380530
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Kenna, Tony
|e verfasserin
|4 aut
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| 245 |
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|a Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver
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|c 2004
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 26.10.2004
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|a Date Revised 15.11.2006
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|a published: Print
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|a Citation Status MEDLINE
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|a Gamma delta T cells are thought to mediate immune responses at epithelial surfaces. We have quantified and characterized hepatic and peripheral blood gamma delta T cells from 11 normal and 13 unresolved tumor-bearing human liver specimens. gamma delta T cells are enriched in normal liver (6.6% of T cells) relative to matched blood (0.9%; P = 0.008). The majority express CD4(-)CD8(-) phenotypes and many express CD56 and/or CD161. In vitro, hepatic gamma delta T cells can be induced to kill tumor cell lines and release interferon-gamma, tumor necrosis factor-alpha, interleukin-2 and interleukin-4. Analysis of V gamma and V delta chain usage indicated that V delta 3(+) cells are expanded in normal livers (21.2% of gamma delta T cells) compared to blood (0.5%; P = 0.001). Tumor-bearing livers had significant expansions and depletions of gamma delta T cell subsets but normal cytolytic activity. This study identifies novel populations of liver T cells that may play a role in immunity against tumors
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Receptors, Antigen, T-Cell, gamma-delta
|2 NLM
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| 700 |
1 |
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|a Golden-Mason, Lucy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Norris, Suzanne
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hegarty, John E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a O'Farrelly, Cliona
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Doherty, Derek G
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 113(2004), 1 vom: 15. Okt., Seite 56-63
|w (DE-627)NLM098196855
|x 1521-6616
|7 nnns
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| 773 |
1 |
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|g volume:113
|g year:2004
|g number:1
|g day:15
|g month:10
|g pages:56-63
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