Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes

Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes

NOD mice spontaneously develop insulitis and type 1 diabetes (T1D) mellitus similar to humans. Insulitis without overt disease occurs in the BDC2.5 TCR-transgenic NOD mice that express the rearranged TCR alpha- and beta-chain genes of a diabetogenic T cell clone reactive to an unknown beta cell auto...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 113(2004), 1 vom: 15. Okt., Seite 29-37
1. Verfasser: Judkowski, Valeria (VerfasserIn)
Weitere Verfasser: Rodriguez, Enrique, Pinilla, Clemencia, Masteller, Emma, Bluestone, Jeffrey A, Sarvetnick, Nora, Wilson, Darcy B
Format: Aufsatz
Sprache:English
Veröffentlicht: 2004
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Blood Glucose Peptides Vaccines