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01000naa a22002652 4500 |
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NLM150538006 |
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DE-627 |
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20231223054052.0 |
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231223s2004 xx ||||| 00| ||eng c |
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|a pubmed24n0502.xml
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|a (DE-627)NLM150538006
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| 035 |
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|a (NLM)15379462
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Nisha, C K
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Water-soluble complexes from random copolymer and oppositely charged surfactant. 2. Complexes of poly(ethylene glycol)-based cationic random copolymer and bile salts
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| 264 |
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1 |
|c 2004
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 21.08.2006
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| 500 |
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|a Date Revised 30.11.2018
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|a published: Print
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|a Citation Status MEDLINE
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|a The complexes formed between the positively charged random copolymers (RCPs) of methoxy-poly(ethylene glycol) monomethacrylate (MePEGMA) and (3-(methacryloylamino)propyl)trimethylammonium chloride (MAPTAC) with oppositely charged biosurfactants (bile salts) were studied using turbidimetric titration, steady-state fluorescence, dynamic light scattering, and electron microscopy. Studies showed that the complexes of the RCPs of MAPTAC and MePEGMA with less than 68 mol % of PEG content precipitate in water, whereas the complexes of the copolymer with 89 and 94 mol % of PEG content do not precipitate in the entire range of composition of the mixture including stoichiometric compositions when the electroneutral complexes are formed. The complexes with true hydrophobic domains, which are a prerequisite characteristic to serve as a carrier, can be obtained at much lower concentration than the critical micelle concentration of the corresponding surfactant. For a particular surfactant, hydrophobic domains are obtained at lower Z-/+ for the random copolymer with lower PEG content. The hydrodynamic radii of these complexes vary over a range of 20-35 nm. Overall results reveal that these complexes are qualitatively similar to the polyion complex micelles or block ionomer complexes obtained from the block copolymers and oppositely charged surfactants. As the surfactants used in this study are biocompatible, we hope that these soluble particles will be promising vectors in the field of drug delivery
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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7 |
|a Bile Acids and Salts
|2 NLM
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| 650 |
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7 |
|a Cations
|2 NLM
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| 650 |
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7 |
|a Macromolecular Substances
|2 NLM
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| 650 |
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7 |
|a Polymers
|2 NLM
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| 650 |
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7 |
|a Surface-Active Agents
|2 NLM
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| 650 |
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7 |
|a Water
|2 NLM
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| 650 |
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7 |
|a 059QF0KO0R
|2 NLM
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| 650 |
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7 |
|a Polyethylene Glycols
|2 NLM
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| 650 |
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7 |
|a 3WJQ0SDW1A
|2 NLM
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| 700 |
1 |
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|a Manorama, Sunkara V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kizhakkedathu, Jayachandran N
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Maiti, Souvik
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 20(2004), 20 vom: 28. Sept., Seite 8468-75
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
8 |
|g volume:20
|g year:2004
|g number:20
|g day:28
|g month:09
|g pages:8468-75
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|a AR
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| 952 |
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|d 20
|j 2004
|e 20
|b 28
|c 09
|h 8468-75
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