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20231223053008.0 |
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|a pubmed24n0500.xml
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|a (DE-627)NLM150035349
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|a (NLM)15324569
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Luo, Xian-qiong
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Expression and action of vascular endothelial growth factor and its receptor in a rat model of retinopathy of prematurity
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| 264 |
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|c 2004
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 02.12.2004
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|a Date Revised 24.11.2016
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To explore the expression of vascular endothelial growth factor (VEGF) and its receptors (flt-1 and flk-1) in the retina of retinopathy of prematurity (ROP), and its relation to the alteration of retinal blood vessels
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| 520 |
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|a METHODS: Eighty-six newborn Sprague-Dawley rats were randomly divided into hyperoxia and air groups, then each group was further divided into 1, 3, 7 and 14 days subgroups. The rats in hyperoxia group inhaled 75% oxygen and ROP model was thus set up. These animals were sacrificed respectively after 1, 3, 7 and 14 days, then the retinal endothelial cells were marked by CD34 to observe the change of retinal blood vessels. The expression of VEGF, flt-1 and flk-1 in the retina was measured by immunohistochemistry
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|a RESULTS: The retinal capillary density index (RCDI) in control group increased as days went on (F = 21.589, P < 0.01, but it was the least on the 7th day in hyperoxia group, after the rats had been returned to air for 7 days, RCDI increased significantly (F = 67.885, P < 0.01); In the control group, the expression of VEGF and flk-1 was the strongest in the retina on the 7th day, the result had significant difference as compared with the 1st and 14th day (P < 0.05). The expression of VEGF and flk-1 on the 7th day in hyperoxia group was weaker than that of control group (P < 0.05). But on the 14th day in hyperoxia group, they were stronger than that of control (P < 0.05). The localization of the expression of flt-1 was changed when blood vessels altered, but there was no significant difference in expression intensity as a whole (P > 0.05)
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|a CONCLUSION: When the premature retina was exposed to hyperoxia, the expression of VEGF and flk-1 was reduced, and retinal blood vessels were also decreased; but the expression of VEGF and flk-1 was stronger in retina when premature rats were exposed to relative hypoxia, and the retinal blood vessels also increased significantly. It is concluded that VEGF and flk-1 may play important roles in the development of retinal blood vessels and its change in ROP. However, flt-1 has less effect compared with flk-1
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|a Comparative Study
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|a Journal Article
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|a Vascular Endothelial Growth Factor A
|2 NLM
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| 650 |
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|a Receptors, Vascular Endothelial Growth Factor
|2 NLM
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| 650 |
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7 |
|a EC 2.7.10.1
|2 NLM
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| 700 |
1 |
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|a Liu, Guo-sheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lai, Ri-quan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nie, Chuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Kun-he
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tian, Ye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xia, Ming-han
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kang, Ju-ling
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 42(2004), 7 vom: 23. Juli, Seite 511-5
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
1 |
8 |
|g volume:42
|g year:2004
|g number:7
|g day:23
|g month:07
|g pages:511-5
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|a AR
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| 952 |
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|d 42
|j 2004
|e 7
|b 23
|c 07
|h 511-5
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