Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice

Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice

Immunodeficient NOD mice engrafted with human peripheral blood mononuclear cells (PBMCs) were used in two models of human islet allograft rejection. Model one: human PBMCs were engrafted into chemically diabetic NOD-scid mice bearing established subrenal human islet allografts. Inflammation and ofte...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 112(2004), 3 vom: 12. Sept., Seite 273-83
1. Verfasser: Banuelos, Scott J (VerfasserIn)
Weitere Verfasser: Shultz, Leonard D, Greiner, Dale L, Burzenski, Lisa M, Gott, Bruce, Lyons, Bonnie L, Rossini, Aldo A, Appel, Michael C
Format: Aufsatz
Sprache:English
Veröffentlicht: 2004
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Blood Glucose HLA-A2 Antigen Membrane Glycoproteins Pore Forming Cytotoxic Proteins Perforin 126465-35-8