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01000caa a22002652 4500 |
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NLM149487215 |
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DE-627 |
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tu |
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231223s2004 xx ||||| 00| ||chi c |
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|a pubmed25n0498.xml
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|a (DE-627)NLM149487215
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|a (NLM)15265434
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Fu, Xue-ming
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Comparison of the effect of ambroxol and dexamethasone on the expression of pulmonary surfactant proteins in the fetal rat lungs
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| 264 |
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1 |
|c 2004
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 09.09.2004
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|a Date Revised 07.06.2016
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To investigate the effects of maternally administered dexamethasone and ambroxol on the mRNA levels of surfactant proteins (SP-A, SP-B and SP-C) expression in fetal rat lungs at gestational age day 19
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| 520 |
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|a METHODS: A 19-day fetal rat lung model was employed. In situ hybridization was used to detect the expression of SP-B mRNA in alveolar type II cell, and the levels of SP-A, SP-B and SP-C mRNAs were detected by semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR)
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| 520 |
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|a RESULTS: (1) SP-B mRNA was detected in situ in alveolar type II cells in fetal rat lung of day 19 gestational age; (2) In the late developmental period of fetal rat lungs, alveolar type II cells were also found around bronchus; (3) Comparing to beta-actin mRNA, the relative values of SP-A, SP-B and SP-C mRNAs were 0.81 +/- 0.26, 0.97 +/- 0.20 and 0.88 +/- 0.11 in fetal lung in the control group. The relative values of mRNAs of SP-A, SP-B and SP-C to beta-actin were 1.04 +/- 0.16, 1.28 +/- 0.29, 1.09 +/- 0.25 in fetal lungs of the ambroxol injected rats, and were 1.08 +/- 0.25, 1.23 +/- 0.35, 1.21 +/- 0.25 in fetal lungs of the dexamethasone injected rats, respectively. Both ambroxol and dexamethasone-treated rats had significantly higher mRNA expression of surfactant proteins compared to the control saline injected animals (P < 0.05). (4) There were no significant differences between ambroxol and dexamethasone in the effects of increasing expressions of surfactant protein mRNAs (P > 0.05)
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| 520 |
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|a CONCLUSION: Antepartum administration of both ambroxol and dexamethasone can significantly increase fetal lung SP-A, SP-B and SP-C mRNAs expression
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| 650 |
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|a Comparative Study
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|a English Abstract
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4 |
|a Journal Article
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| 650 |
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7 |
|a Expectorants
|2 NLM
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| 650 |
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7 |
|a Glucocorticoids
|2 NLM
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| 650 |
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7 |
|a Pulmonary Surfactant-Associated Protein A
|2 NLM
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| 650 |
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7 |
|a Pulmonary Surfactant-Associated Protein B
|2 NLM
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| 650 |
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7 |
|a Pulmonary Surfactant-Associated Protein C
|2 NLM
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| 650 |
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7 |
|a Pulmonary Surfactant-Associated Proteins
|2 NLM
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| 650 |
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7 |
|a RNA, Messenger
|2 NLM
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| 650 |
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7 |
|a Ambroxol
|2 NLM
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| 650 |
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7 |
|a 200168S0CL
|2 NLM
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| 650 |
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7 |
|a Dexamethasone
|2 NLM
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| 650 |
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7 |
|a 7S5I7G3JQL
|2 NLM
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| 700 |
1 |
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|a Yu, Jia-lin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Guan-xin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Deng, Bing
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 42(2004), 6 vom: 22. Juni, Seite 450-3
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
1 |
8 |
|g volume:42
|g year:2004
|g number:6
|g day:22
|g month:06
|g pages:450-3
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_11
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|a GBV_ILN_20
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|a GBV_ILN_22
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|a GBV_ILN_24
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|a GBV_ILN_31
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|a GBV_ILN_39
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|a GBV_ILN_40
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|a GBV_ILN_50
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|a GBV_ILN_61
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|a GBV_ILN_65
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|a GBV_ILN_69
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|a GBV_ILN_70
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|a GBV_ILN_72
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|a GBV_ILN_120
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| 912 |
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|a GBV_ILN_130
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|a GBV_ILN_227
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|a GBV_ILN_244
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|a GBV_ILN_285
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|a GBV_ILN_294
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|a GBV_ILN_350
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|a GBV_ILN_665
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|a GBV_ILN_813
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|a AR
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| 952 |
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|d 42
|j 2004
|e 6
|b 22
|c 06
|h 450-3
|