Clinical significance of pancreatic beta-cell function in obese children with acanthosis nigricans

Clinical significance of pancreatic beta-cell function in obese children with acanthosis nigricans

OBJECTIVE: The strong relation between type 2 diabetes mellitus and obesity with acanthosis nigricans is widely concerned. This study investigated the pancreatic beta-cell function in obese children with acanthosis nigricans, so as to find out the role of insulin secretion and insulin resistance in...

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Veröffentlicht in:Zhonghua er ke za zhi = Chinese journal of pediatrics. - 1960. - 42(2004), 6 vom: 22. Juni, Seite 405-7
1. Verfasser: Liang, Xue-jun (VerfasserIn)
Weitere Verfasser: Zhu, Cheng, Yan, Chun, Ni, Gui-chen, Liu, Zhong-liang, Du, Zhong-min, Li, Ming
Format: Aufsatz
Sprache:Chinese
Veröffentlicht: 2004
Zugriff auf das übergeordnete Werk:Zhonghua er ke za zhi = Chinese journal of pediatrics
Schlagworte:Comparative Study English Abstract Journal Article C-Peptide Insulin Proinsulin 9035-68-1
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245 1 0 |a Clinical significance of pancreatic beta-cell function in obese children with acanthosis nigricans 
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500 |a Date Completed 09.09.2004 
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500 |a Citation Status MEDLINE 
520 |a OBJECTIVE: The strong relation between type 2 diabetes mellitus and obesity with acanthosis nigricans is widely concerned. This study investigated the pancreatic beta-cell function in obese children with acanthosis nigricans, so as to find out the role of insulin secretion and insulin resistance in obese children with acanthosis nigricans 
520 |a METHODS: Thirty-five obese children with acanthosis nigricans (19 males and 16 females with mean age 12.8 +/- 1.5 years) were enrolled in this study. Thirty-eight obese children (21 boys and 17 girls with mean age 11.9 +/- 2.6 years) and 39 normal children (20 boys and 19 girls with mean age 11.2 +/- 2.2 years) were recruited as obese and normal control groups. The levels of serum fasting insulin, C-peptide, proinsulin and true insulin were measured in all the subjects. The ratios of proinsulin/insulin and proinsulin/C-peptide were calculated. Homeostasis model assessment was applied to assess the status of insulin resistance and basic function of pancreatic beta-cell 
520 |a RESULTS: The levels of fasting insulin, C-peptide proinsulin, true insulin, the ratios of proinsulin/insulin and proinsulin/C-peptide, insulin resistance index and insulin secretion index of obese children with acanthosis nigricans, obese control children and normal control children were: 18.5 (5.0-60.5) pmol/L, 12.4 (6.1-35.8) pmol/L and 5.1 (2.0-32.8) pmol/L; 3.9 (1.3-14.0) microg/L, 2.4 (1.1-4.0) microg/L and 1.1 (1.0-4.2) microg/L; 28.8 (9.9-64.2) pmol/L, 9.5 (2.2-34.5) pmol/L and 4.2 (2.0-16.0) pmol/L; 33.0 (6.2-66.0) pmol/L, 10.6 (4.8-29.4) pmol/L and 4.5 (1.3-30.1) pmol/L; 1.2 (0.4-8.9), 0.9 (0.2-1.9) and 0.8 (0.4-2.0); 6.9 (2.5-36.6), 4.7 (1.2-12.3) and 3.6 (1.2-9.6); 5.0 (0.8-14.1), 2.6 (1.3-8.1) and 1.2(0.4-6.9); 303.3 (52.2-1,163.8), 213.6 (84.6-572.0) and 51.1 (19.1-561.4). The levels of fasting insulin, C-peptide, proinsulin, true insulin, the ratios of proinsulin/insulin and proinsulin/C-peptide, insulin resistance index and insulin secretion index in obese children with acanthosis nigricans were significantly higher than those in obese children (P < 0.001) and normal children (P < 0.001) 
520 |a CONCLUSION: Obese children with acanthosis nigricans had higher insulin resistance and pancreatic beta-cell dysfunction; acanthosis nigricans may be a skin sign of high risk of type 2 diabetes mellitus 
650 4 |a Comparative Study 
650 4 |a English Abstract 
650 4 |a Journal Article 
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700 1 |a Zhu, Cheng  |e verfasserin  |4 aut 
700 1 |a Yan, Chun  |e verfasserin  |4 aut 
700 1 |a Ni, Gui-chen  |e verfasserin  |4 aut 
700 1 |a Liu, Zhong-liang  |e verfasserin  |4 aut 
700 1 |a Du, Zhong-min  |e verfasserin  |4 aut 
700 1 |a Li, Ming  |e verfasserin  |4 aut 
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