Vaccination with dendritic cells pulsed in vitro with tumor antigen conjugated to cholera toxin efficiently induces specific tumoricidal CD8+ cytotoxic lymphocytes dependent on cyclic AMP activation of dendritic cells

Vaccination with dendritic cells pulsed in vitro with tumor antigen conjugated to cholera toxin efficiently induces specific tumoricidal CD8+ cytotoxic lymphocytes dependent on cyclic AMP activation of dendritic cells

We investigated the development of CD8+ tumor-specific cytotoxic lymphocytes (CTL) and protection against tumor growth after vaccination with bone marrow-derived dendritic cells (DC) pulsed with a model protein ovalbumin conjugated to cholera toxin (OVA-CT) in B6 mice using E.G7 tumor cells expressi...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 112(2004), 1 vom: 16. Juli, Seite 35-44
1. Verfasser: Sun, J-B (VerfasserIn)
Weitere Verfasser: Eriksson, K, Li, B-L, Lindblad, M, Azem, J, Holmgren, J
Format: Aufsatz
Sprache:English
Veröffentlicht: 2004
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Adjuvants, Immunologic Antigens, Neoplasm Egg Proteins Immunotoxins OVA-8 Peptide Fragments Interferon-gamma 82115-62-6 mehr... Ovalbumin 9006-59-1 Cholera Toxin 9012-63-9 Cyclic AMP E0399OZS9N