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01000naa a22002652 4500 |
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NLM147873401 |
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DE-627 |
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20231223044322.0 |
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tu |
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231223s2004 xx ||||| 00| ||eng c |
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2 |
|a pubmed24n0493.xml
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|a (DE-627)NLM147873401
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|a (NLM)15093557
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Fiore, Lucia
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Search for poliovirus long-term excretors among patients affected by agammaglobulinemia
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| 264 |
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1 |
|c 2004
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 27.05.2004
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| 500 |
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|a Date Revised 15.11.2006
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| 500 |
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|a published: Print
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Patients with agammaglobulinemia may excrete enteroviruses, including vaccine-derived poliovirus, for prolonged periods of time. This poses a risk to the patients but it also may pose a risk to the population after eradication of poliovirus and the cessation of routine vaccination. To assess this risk, a pilot study was performed to identify potential poliovirus long-term excretors in a cohort of 38 patients with a definite/presumptive diagnosis of X-linked agammaglobulinemia (XLA). Stool samples were analyzed to detect any polio or other enteroviruses replicating in the gut and neutralizing antibodies against polioviruses were measured in the sera. No viruses were isolated from the stool samples and most sera had neutralizing antibody levels against all three poliovirus serotypes considered by the WHO to be protective in immunocompetent individuals. This suggests that long-term excretion of enteroviruses in patients with agammaglobulinemia is relatively uncommon
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antibodies, Viral
|2 NLM
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| 650 |
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7 |
|a Poliovirus Vaccine, Oral
|2 NLM
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| 700 |
1 |
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|a Plebani, Alessandro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Buttinelli, Gabriele
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fiore, Stefano
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Donati, Valentina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Marturano, Jill
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Soresina, Annarosa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Martire, Baldassarre
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Azzari, Chiara
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nigro, Giovanni
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cardinale, Fabio
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Trizzino, Antonino
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pignata, Claudio
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Alvisi, Patrizia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Anastasio, Elisa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bossi, Grazia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ugazio, Alberto G
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 111(2004), 1 vom: 01. Apr., Seite 98-102
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:111
|g year:2004
|g number:1
|g day:01
|g month:04
|g pages:98-102
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 111
|j 2004
|e 1
|b 01
|c 04
|h 98-102
|