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231223s2004 xx ||||| 00| ||eng c |
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|a pubmed25n0491.xml
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|a (DE-627)NLM147217288
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|a (NLM)15022200
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Lee, Wonjae
|e verfasserin
|4 aut
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|a Chiral discrimination studies of (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid by high-performance liquid chromatography and NMR spectroscopy
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|c 2004
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 15.03.2005
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|a Date Revised 10.12.2019
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|a published: Print
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|a Citation Status MEDLINE
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|a 2004 John Wiley & Sons, Ltd.
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|a Chiral discrimination studies using (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) as a chiral selector were performed by high-performance liquid chromatography (HPLC) and NMR spectroscopy. The enantiomers of alanine (Ala) or alanine methyl ester (Ala-ME) were well separated on the chiral stationary phases (CSPs) derived from (+)-18-C-6-TA by HPLC. The chiral selector, (+)-18-C-6-TA, used in the CSP was also applied for the chiral discrimination of the Ala and Ala-ME enantiomers, and it discriminated these enantiomers successfully by NMR spectroscopy. The chemical shift differences (Delta Delta delta) of the alpha-proton of these enantiomers in the presence of an equimolecular solution of 18-C-6-TA were observed to be 0.10 ppm for Ala in methanol-d4 containing 10 mM H2SO4 and 0.11 ppm for Ala-ME in methanol-d4. The observed NMR results agreed with the chromatographic data on the (+)-18-C-6-TA-derived CSP by HPLC in terms of both the elution order and solvents effects
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|a Comparative Study
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|a Evaluation Study
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Crown Ethers
|2 NLM
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|a Solvents
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|a 18-crown-6 2,3,11,12-tetracarboxylic acid
|2 NLM
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|a 119719-58-3
|2 NLM
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| 700 |
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|a Bang, Eunjung
|e verfasserin
|4 aut
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|a Baek, Chae-Sun
|e verfasserin
|4 aut
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| 700 |
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|a Lee, Weontae
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 42(2004), 4 vom: 15. Apr., Seite 389-95
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnas
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| 773 |
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|g volume:42
|g year:2004
|g number:4
|g day:15
|g month:04
|g pages:389-95
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|d 42
|j 2004
|e 4
|b 15
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|h 389-95
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