Activation of human mast cells by aggregated IgG through FcgammaRI additive effects of C3a

Activation of human mast cells by aggregated IgG through FcgammaRI : additive effects of C3a

Human mast cells (huMC) increase surface expression of FcgammaRI (CD64) in response to IFNgamma. Subsequent receptor aggregation of FcgammaR1 using CD64-specific F(ab')(2) or antibody directed against FcgammaR1-bound IgG results in cell activation. Human mast cells may be observed degranulating...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 110(2004), 2 vom: 14. Feb., Seite 172-80
1. Verfasser: Woolhiser, Michael R (VerfasserIn)
Weitere Verfasser: Brockow, Knut, Metcalfe, Dean D
Format: Aufsatz
Sprache:English
Veröffentlicht: 2004
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, U.S. Gov't, P.H.S. Cytokines Immunoglobulin G RNA, Messenger Receptors, IgG Leukotriene C4 2CU6TT9V48 Complement C3a 80295-42-7 mehr... Interferon-gamma 82115-62-6 beta-N-Acetylhexosaminidases EC 3.2.1.52 Prostaglandin D2 RXY07S6CZ2