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01000naa a22002652 4500 |
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NLM147048737 |
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DE-627 |
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20231223042516.0 |
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tu |
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231223s2004 xx ||||| 00| ||eng c |
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|a pubmed24n0490.xml
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|a (DE-627)NLM147048737
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|a (NLM)15003813
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Kano, Hirotsugu
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Critical role of T cell migration in bacterial superantigen-mediated shock in mice
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| 264 |
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1 |
|c 2004
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 15.04.2004
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|a Date Revised 21.11.2008
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a Bacterial superantigens have been implicated in the pathogenesis of several human diseases. Among them, toxic shock syndrome (TSS) is a prototypic acute intoxication caused by the pyrogenic exotoxin family of superantigens. In this study, we investigated the pathophysiological mechanism of TSS using the Yersinia pseudotuberculosis-derived mitogen (YPM) and its point mutants. The results indicated that YPM could induce toxic shock in BALB/c mice but not in T cell-deficient SCID mice. We found that Vbeta8(+) T cells activated by YPM migrated from peripheral blood to liver as early as 1 h after injection of YPM and that serum level of IFN-gamma was significantly elevated 4 h after YPM injection. Co-administration of anti-IFN-gamma antibody or anti-YPM monoclonal antibody alleviated the liver injury and protected mice from YPM-induced death. Moreover, anti-YPM antibody also suppressed the early migration of Vbeta8(+) T cells from the peripheral circulation and the elevation of serum IFN-gamma level, indicating a pivotal role of T cells in inducing shock in our mouse model
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| 650 |
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|a Journal Article
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| 650 |
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7 |
|a Bacterial Proteins
|2 NLM
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| 650 |
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7 |
|a Superantigens
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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7 |
|a Yersinia pseudotuberculosis-derived mitogen
|2 NLM
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| 650 |
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7 |
|a Interleukin-10
|2 NLM
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| 650 |
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7 |
|a 130068-27-8
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Ito, Yasuhiko
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Matsuoka, Kentaro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nakajima, Toshiharu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Iwata, Tsutomu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kohsaka, Takao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Saito, Hirohisa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Abe, Jun
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 110(2004), 2 vom: 14. Feb., Seite 159-71
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:110
|g year:2004
|g number:2
|g day:14
|g month:02
|g pages:159-71
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|d 110
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|h 159-71
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