Aberrant signaling in the TNFalpha/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse

Aberrant signaling in the TNFalpha/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse

The purpose of this study was to evaluate the ability to induce TNFalpha-dependent apoptosis in vivo in predisease lupus-prone NZM2410 and derived B6.NZM congenic mouse strains. An endotoxicosis model that utilizes LPS and d-galactosamine to induce mortality by TNFalpha/TNFR1-dependent hepatocyte ap...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 110(2004), 2 vom: 14. Feb., Seite 124-33
1. Verfasser: Blenman, Kim R M (VerfasserIn)
Weitere Verfasser: Bahjat, Frances R, Moldawer, Lyle L, Morel, Laurence
Format: Aufsatz
Sprache:English
Veröffentlicht: 2004
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, U.S. Gov't, P.H.S. Antigens, CD Interleukin-6 Lipopolysaccharides Receptors, Tumor Necrosis Factor Receptors, Tumor Necrosis Factor, Type I Tumor Necrosis Factor-alpha Interleukin-10 130068-27-8 mehr... Galactosamine 7535-00-4 Aspartate Aminotransferases EC 2.6.1.1 Casp3 protein, mouse EC 3.4.22.- Caspase 3 Caspases