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|a (DE-627)NLM144544377
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|a (NLM)14748997
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Chen, Jing
|e verfasserin
|4 aut
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| 245 |
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|a Application of CD34+ autologous peripheral progenitor cell transplant in the treatment of children with refractory SLE
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|c 2003
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 06.05.2004
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|a Date Revised 07.06.2016
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: Systematic lupus erythematosis (SLE) is a severe disease which affects the patient for many years and there is no radical cure for the disease. To explore a possible way to treat children with refractory SLE, the authors treated 2 children with grade III and IV lupus nephropathy for 5 years and 7 years respectively, mainly presented with persistent thrombocytopenia, proteinuria, pleural effusion with CD34(+) autologous peripheral progenitor cells transplantation
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|a METHODS: Mobilized with G-CSF and collected with CS-3000 Cell Separator, passed through the CliniMacs CD34(+) cell selection device, the count of CD34(+) cells obtained reached 1.0 x 10(6)/kg and 1.7 x 10(6)/kg, respectively with the remaining of 2.0 x 10(5)/kg and 1.0 x 10(4)/kg of CD3(+) cells individually. The selected CD34(+) cells were frozen at -80 degrees C. The conditioning regimen consisted of cyclophosphamide [50 mg/(kg x day) for 4 days] plus ATG [Fresennius S 5 mg/(kg x day) for 3 days]. After 48 h treatment with cyclophosphamide, the frozen stem cells were infused back to the patients
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|a RESULTS: Neutrophils recovered on 9 and 7 days after transplantation respectively in these 2 cases. Beginning from 15 days, the platelet count recovered and remained at over 100 x 10(9)/L. The sign of Cushing's syndrome disappeared completely 3 months after transplantation because discontinuing the steroid. One child's height had a 5 cm increase within 6 months after stopping steroid and this was the first height gain during the 7 years since she had had the disease. Till this paper was written, these 2 children were followed up for 13 months and 6 months, respectively, all the original symptoms and autoantibodies related to autoimmune disorders disappeared. But the cell-mediated immunity did not recover yet with the CD4(+) cell level still remained at a lower level
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|a CONCLUSION: The effect of CD34(+) autologous peripheral progenitor cell transplantation on the children with refractory SLE was satisfactory so far, but the long-term effect remains to be confirmed by further studies on more cases
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|a Case Reports
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|a English Abstract
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|a Journal Article
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|a Antigens, CD34
|2 NLM
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|a Gu, Long-jun
|e verfasserin
|4 aut
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|a Zhao, Hui-jun
|e verfasserin
|4 aut
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1 |
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|a Xue, Hui-liang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zheng, Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Xiao-juan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Jing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Li
|e verfasserin
|4 aut
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| 700 |
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|a Xu, Chong
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Yao-ping
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 41(2003), 6 vom: 29. Juni, Seite 426-9
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|x 0578-1310
|7 nnns
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| 773 |
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|g volume:41
|g year:2003
|g number:6
|g day:29
|g month:06
|g pages:426-9
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