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01000naa a22002652 4500 |
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NLM144513749 |
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DE-627 |
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20231223033347.0 |
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231223s2004 xx ||||| 00| ||eng c |
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|a pubmed24n0482.xml
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|a (DE-627)NLM144513749
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|a (NLM)14745795
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Moraes, Cléria Mendonça
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Peptide-related alterations of membrane-associated water
|b deuterium solid-state NMR investigations of phosphatidylcholine membranes at different hydration levels
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1 |
|c 2004
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 22.03.2005
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright 2004 John Wiley & Sons, Ltd.
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|a Deuterated water associated with oriented POPC bilayers was investigated before and after the addition of 2 mol% peptide. Membranes in the presences of antimicrobial-(LAH4), pore-forming- (the segments M2 of influenza A and S4 of the domain I of rat brain sodium channels) or lysine-containing model peptides (LAK1 and LAK3) were investigated by (2)H and proton-decoupled (31)P solid-state NMR. The NMR spectra were recorded as a function of hydration in the range between 15 and 93% relative humidity and of sample composition. In the presence of peptides an increased association of water is observed. A quantitative analysis suggests that the peptide-induced changes in the lipid bilayer packing have a significant effect on membrane-water association. The quadrupolar splittings of (2)H(2)O at a given degree of hydration indicate that the changes of the water deuterium order parameter are specific for the peptide sequence and the lipid composition
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Liposomes
|2 NLM
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| 650 |
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7 |
|a Membranes, Artificial
|2 NLM
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| 650 |
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7 |
|a Nerve Tissue Proteins
|2 NLM
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| 650 |
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7 |
|a Peptides
|2 NLM
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| 650 |
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|a Phosphatidylcholines
|2 NLM
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| 650 |
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|a Sodium Channels
|2 NLM
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| 650 |
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|a Water
|2 NLM
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| 650 |
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|a 059QF0KO0R
|2 NLM
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| 650 |
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|a Deuterium
|2 NLM
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| 650 |
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7 |
|a AR09D82C7G
|2 NLM
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| 650 |
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|a 1-palmitoyl-2-oleoylphosphatidylcholine
|2 NLM
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| 650 |
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|a TE895536Y5
|2 NLM
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| 700 |
1 |
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|a Bechinger, Burkhard
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 42(2004), 2 vom: 15. Feb., Seite 155-61
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
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| 773 |
1 |
8 |
|g volume:42
|g year:2004
|g number:2
|g day:15
|g month:02
|g pages:155-61
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 42
|j 2004
|e 2
|b 15
|c 02
|h 155-61
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