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NLM143738534 |
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DE-627 |
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20250205051045.0 |
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tu |
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231223s2003 xx ||||| 00| ||chi c |
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|a pubmed25n0479.xml
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|a (DE-627)NLM143738534
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| 035 |
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|a (NLM)14659051
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Jiang, Du-yin
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Clinical significance of detection of serum hyaluronic acid concentration in severe burn patients
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| 264 |
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1 |
|c 2003
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 06.05.2004
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| 500 |
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|a Date Revised 15.11.2006
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| 500 |
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To study the relationship between the changes in serum hyaluronic acid (HA) concentrations and injury of hepatocytes in severe burn patients
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| 520 |
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|a METHODS: Radioimmunoassay and enzyme-linked immunosorbent assay (ELISA) were used to detect HA and tumor necrosis factor-alpha(TNF-alpha) concentrations in serum, and biochemical indexes for hepatic function and renal function in burn patients that were divided into different groups: systemic inflammatory response syndrome(SIRS), multiple organ dysfunction syndrome(MODS). Multiple organ failure(MOF) and non-surviving patient groups
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| 520 |
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|a RESULTS: In two weeks after burns, the serum HA concentration attained a high level. With the increase of severity of disease, the values of the serum HA concentration were elevated progressively (P<0.001). At the onset of MOF till death, the serum HA content was rapidly decreased. Lineal correlation analysis indicated that the change in the serum HA concentration was closely correlated with SIRS, burn sepsis, MODS and death (P<0.01). It was positively correlated with TNF-alpha, aspartate aminotransferase (AST) and total bilirubin (P<0.05 or P<0.01), and negatively correlated with plasma albumin and albumin/globulin(both P<0.05)
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| 520 |
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|a CONCLUSION: The increment in serum HA levels is relate with the impairment of the hepatic endothelial cells due to TNF-alpha etc. The HA content in serum can be used as a sensitive indicator for judging injury of liver, seriousness of the injury, and prognosis of the patient
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| 650 |
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|a English Abstract
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| 650 |
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4 |
|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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7 |
|a Hyaluronic Acid
|2 NLM
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| 650 |
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7 |
|a 9004-61-9
|2 NLM
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| 700 |
1 |
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|a Zhou, Bing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fu, Xiao-bing
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 15(2003), 12 vom: 15. Dez., Seite 718-21
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:15
|g year:2003
|g number:12
|g day:15
|g month:12
|g pages:718-21
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 15
|j 2003
|e 12
|b 15
|c 12
|h 718-21
|