Crystal structure of a humanized Fab fragment of anti-tissue-factor antibody in complex with tissue factor
Tissue factor (TF) is a membrane-anchored protein that initiates the extrinsic cascade of blood coagulation. TF forms a complex with serine protease Factor VIIa, and then activates Factor X zymogen to Factor Xa, leading to the blood coagulation. Humanized anti-TF antibody hATR-5 strongly inhibits TF...
| Veröffentlicht in: | Journal of synchrotron radiation. - 1994. - 11(2004), Pt 1 vom: 01. Jan., Seite 105-8 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2004
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| Zugriff auf das übergeordnete Werk: | Journal of synchrotron radiation |
| Schlagworte: | Comparative Study Journal Article Antibodies Immunoglobulin Fab Fragments Macromolecular Substances Thromboplastin 9035-58-9 |