Crystal structure of the complex of porcine pancreatic elastase with TEI-8362
The crystal structure of porcine pancreatic elastase (PPE) complexed with a new benzoxazinone inhibitor, TEI-8362, of human neutrophil elastase (HNE) was determined at 1.8 A resolution. The hydroxyl oxygen of Ser195 opened the benzoxazinone by nucleophilic attack and formed a covalent bond with the...
| Veröffentlicht in: | Journal of synchrotron radiation. - 1994. - 11(2004), Pt 1 vom: 01. Jan., Seite 101-4 |
|---|---|
| 1. Verfasser: | |
| Weitere Verfasser: | , , |
| Format: | Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2004
|
| Zugriff auf das übergeordnete Werk: | Journal of synchrotron radiation |
| Schlagworte: | Journal Article Butyrates Carbamates Enzyme Inhibitors Macromolecular Substances TEI 8362 Pancreatic Elastase EC 3.4.21.36 |