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01000naa a22002652 4500 |
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NLM143074970 |
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DE-627 |
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231223s2003 xx ||||| 00| ||eng c |
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|a eng
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| 100 |
1 |
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|a Fitzpatrick, David R
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Methylation and demethylation in the regulation of genes, cells, and responses in the immune system
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| 264 |
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|c 2003
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|b nc
|2 rdacarrier
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|a Date Completed 02.12.2003
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|a Date Revised 08.11.2019
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|a published: Print
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|a Citation Status MEDLINE
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|a DNA methylation is a focus of epigenetic research in the immune system. This overview begins with a synopsis of the players and processes involved in DNA methylation, demethylation, methyl-CpG-recognition, histone modification, and chromatin remodeling. The role of these mechanisms in immune responses, with a focus on T lymphocytes, is then reviewed. There is evidence for epigenetic regulation of several key immune processes including thymocyte development, antigen presentation, differentiation, cytokine expression, effector function, and memory. DNA methylation contributes, along with other epigenetic mechanisms, to the establishment of transcriptional thresholds that vary between genes and T cell types. The immune system is a fertile field for studies of epigenetic regulation of cell fate and function
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, U.S. Gov't, P.H.S.
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|a Review
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|a DNA-Binding Proteins
|2 NLM
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|a Histones
|2 NLM
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| 700 |
1 |
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|a Wilson, Christopher B
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 109(2003), 1 vom: 30. Okt., Seite 37-45
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|g volume:109
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|d 109
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