Change in intestinal free radical and prostaglandin metabolism in the aged rats with pneumococcus pneumonia
OBJECTIVE: To study the pathogenic mechanism underlying intestinal injury in the aged rat with pneumonia
| Veröffentlicht in: | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. - 1998. - 15(2003), 10 vom: 13. Okt., Seite 618-21 |
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| Weitere Verfasser: | , |
| Format: | Aufsatz |
| Sprache: | Chinese |
| Veröffentlicht: |
2003
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| Zugriff auf das übergeordnete Werk: | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Free Radicals Prostaglandins Nitric Oxide 31C4KY9ESH Malondialdehyde 4Y8F71G49Q Thromboxane B2 54397-85-2 mehr... |
| Zusammenfassung: | OBJECTIVE: To study the pathogenic mechanism underlying intestinal injury in the aged rat with pneumonia METHODS: The model of rats with pneumococcus pneumonia was reproduced, and animals were divided into young control group (YCG), young model group (YMG), aged control group (ACG) and aged model group (AMG). The pathological change of lung tissue and intestine, contents of intestinal 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)), thromboxane B(2) (TXB(2)), nitric oxide (NO), malondialdehyde (MDA) and superoxide dismutase (SOD) activity were determined in various groups RESULTS: The lung and intestinal injury in AMG was more serious than that in the YMG. The decreases in SOD activity and 6-keto-PGF(1alpha) content, the increases in contents of TXB(2), NO, MDA in the YMG and the AMG were obvious than those in the YCG and the ACG respectively. The decrease in SOD activity and increase in MDA content were obvious in the ACG than those in the YCG. In addition, the decrease in SOD activity and increase in MDA content in the AMG were significant compared with those in the YMG CONCLUSION: The Prostaglandin metabolism and the free radical injury might be in the pathogenesis of intestinal injury in the aged rats with pneumonia. The intestinal injury induced by free radical in aged rats with pneumonia appears to be more obvious with ageing |
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| Beschreibung: | Date Completed 09.03.2004 Date Revised 30.11.2018 published: Print Citation Status MEDLINE |
| ISSN: | 1003-0603 |