CCR5 promoter polymorphism determines macrophage CCR5 density and magnitude of HIV-1 propagation in vitro

CCR5 promoter polymorphism determines macrophage CCR5 density and magnitude of HIV-1 propagation in vitro

The common CCR5 promoter polymorphism at position -2459 (A/G) has been associated with differences in the rate of progression to AIDS, where HIV-1-infected individuals with the CCR5 -2459 G/G genotype exhibit slower disease progression than those with the A/A genotype. Mechanisms underlying the rela...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 108(2003), 3 vom: 19. Sept., Seite 234-40
1. Verfasser: Salkowitz, Janelle R (VerfasserIn)
Weitere Verfasser: Bruse, Shannon E, Meyerson, Howard, Valdez, Hernan, Mosier, Donald E, Harding, Clifford V, Zimmerman, Peter A, Lederman, Michael M
Format: Aufsatz
Sprache:English
Veröffentlicht: 2003
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S. Chemokine CCL4 Chemokine CCL5 Lipopolysaccharide Receptors Macrophage Inflammatory Proteins Receptors, CCR5