Expansion of clonotype-restricted HLA-identical maternal CD4+ T cells in a patient with severe combined immunodeficiency and a homozygous mutation in the Artemis gene

Expansion of clonotype-restricted HLA-identical maternal CD4+ T cells in a patient with severe combined immunodeficiency and a homozygous mutation in the Artemis gene

We have observed a male infant with severe combined immunodeficiency (SCID) responsible for Artemis gene mutation, in whom marked expansion of the transplacentally grafted maternal CD4(+) T cells was observed in various tissues. His class I and II major histocompatibility antigens (MHC) were identic...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 108(2003), 2 vom: 15. Aug., Seite 159-66
1. Verfasser: Kobayashi, Norimoto (VerfasserIn)
Weitere Verfasser: Agematsu, Kazunaga, Nagumo, Haruo, Yasui, Kozo, Katsuyama, Yoshihiko, Yoshizawa, Kaname, Ota, Masao, Yachie, Akihiro, Komiyama, Atsushi
Format: Aufsatz
Sprache:English
Veröffentlicht: 2003
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Case Reports Comparative Study Journal Article Complementarity Determining Regions DNA-Binding Proteins HLA Antigens Nuclear Proteins Receptors, Antigen, T-Cell, alpha-beta DCLRE1C protein, human EC 3.1.- Endonucleases