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01000naa a22002652 4500 |
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NLM126744726 |
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DE-627 |
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20231222212524.0 |
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tu |
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231222s2003 xx ||||| 00| ||eng c |
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|a pubmed24n0423.xml
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|a (DE-627)NLM126744726
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|a (NLM)12921757
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Losier, Martine
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Virion-bound ICAM-1 and activated LFA-1
|b a combination of factors conferring resistance to neutralization by sera from human immunodeficiency virus type 1-infected individuals independently of the disease status and phase
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| 264 |
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1 |
|c 2003
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 01.10.2003
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| 500 |
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|a Date Revised 07.11.2019
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a The role of the supplementary interaction between virion-bound host ICAM-1 and LFA-1 on target cells in sensitivity to neutralization of human immunodeficiency virus type 1 (HIV-1) is poorly studied. Serum samples from four long-term nonprogressors (LTNPs) and sequential sera from one progressor were used to assess neutralization sensitivity of isogenic ICAM-1-negative and ICAM-1-bearing HIV-1(NL4-3), a prototype of T-cell-line-adapted viruses. We found that virus neutralization sensitivity to the studied sera is not modified by the additional interaction between virally embedded ICAM-1 and LFA-1 under an inactive state. However, expression on the target cell surface of an activated LFA-1 form renders ICAM-1-bearing virus particles, but not viruses devoid of ICAM-1, more refractory to neutralization by sera from three out of four LTNPs and all sequential sera from the person who has experienced a progression of the HIV-1-associated disease. Although no conclusive correlation could be drawn between virus susceptibility to neutralization and the disease status or stages of HIV-1 infection, these findings demonstrate that other nonspecific virus-cell interactions mediated by virion-anchored host proteins and their normal cognate ligands on target cells represent factors that can affect the mechanism of HIV-1 neutralization
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| 650 |
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|a Comparative Study
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| 650 |
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a HIV Antibodies
|2 NLM
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| 650 |
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|a Immune Sera
|2 NLM
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| 650 |
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7 |
|a Lymphocyte Function-Associated Antigen-1
|2 NLM
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| 650 |
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7 |
|a Intercellular Adhesion Molecule-1
|2 NLM
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| 650 |
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|a 126547-89-5
|2 NLM
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| 650 |
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|a Luciferases
|2 NLM
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| 650 |
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7 |
|a EC 1.13.12.-
|2 NLM
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| 700 |
1 |
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|a Fortin, Jean François
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cantin, Réjean
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bergeron, Michel G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tremblay, Michel J
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 108(2003), 2 vom: 15. Aug., Seite 111-8
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:108
|g year:2003
|g number:2
|g day:15
|g month:08
|g pages:111-8
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 108
|j 2003
|e 2
|b 15
|c 08
|h 111-8
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