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01000naa a22002652 4500 |
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NLM126744696 |
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DE-627 |
| 005 |
20231222212524.0 |
| 007 |
tu |
| 008 |
231222s2003 xx ||||| 00| ||eng c |
| 028 |
5 |
2 |
|a pubmed24n0423.xml
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| 035 |
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|a (DE-627)NLM126744696
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| 035 |
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|a (NLM)12921753
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Deocharan, Bisram
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Differential effects of interleukin-4 in peptide induced autoimmunity
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| 264 |
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1 |
|c 2003
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 01.10.2003
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| 500 |
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|a Date Revised 07.11.2019
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| 500 |
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|a published: Print
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|a CommentIn: Clin Immunol. 2003 Aug;108(2):73-9. - PMID 12921752
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a BALB/c mice immunized with multimeric DWEYSVWLSN develop IgG1 anti-DNA antibodies and glomerular immunoglobulin deposits, leading us to investigate the role of IL-4 in this model of antigen induced lupus. Splenocytes from DWEYSVWLSN immunized mice secreted IL-4 but not gamma-interferon. Following peptide immunization, IgG1 anti-peptide and anti-DNA antibodies were significantly higher in IL-4 wild type mice, while IgM and IgG3 anti-DNA levels were significantly higher in IL-4 knockout mice. Titers of IgG anti-laminin and anti-histone, but not anti-Sm/RNP and anti-cardiolipin antibodies, were significantly higher in the IL-4 wild type group. Glomerular immunoglobulin deposition was substantially decreased in IL-4 knockout mice. We conclude that while IL-4 does not materially affect the generation of some autoantibody responses associated with peptide induced autoimmunity, IL-4 deficiency inhibits kidney immunoglobulin deposition. The effect of IL-4 on humoral autoimmunity in lupus is complex, and is dependent on genetic background, the antigenic trigger and stage of disease
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| 650 |
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4 |
|a Comparative Study
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Research Support, U.S. Gov't, P.H.S.
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| 650 |
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7 |
|a Autoantibodies
|2 NLM
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| 650 |
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7 |
|a Histones
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin G
|2 NLM
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| 650 |
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7 |
|a Immunoglobulin M
|2 NLM
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| 650 |
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7 |
|a Laminin
|2 NLM
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| 650 |
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7 |
|a Peptides
|2 NLM
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| 650 |
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7 |
|a Interleukin-4
|2 NLM
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| 650 |
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7 |
|a 207137-56-2
|2 NLM
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| 650 |
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7 |
|a DNA
|2 NLM
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| 650 |
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7 |
|a 9007-49-2
|2 NLM
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| 700 |
1 |
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|a Marambio, Paola
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Edelman, Morris
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Putterman, Chaim
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 108(2003), 2 vom: 15. Aug., Seite 80-8
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:108
|g year:2003
|g number:2
|g day:15
|g month:08
|g pages:80-8
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 951 |
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|a AR
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| 952 |
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|d 108
|j 2003
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|h 80-8
|