Mutational effects on protein folding stability and antigenicity the case of streptococcal pyrogenic exotoxin A

Mutational effects on protein folding stability and antigenicity : the case of streptococcal pyrogenic exotoxin A

The influence of mutationally induced changes in protein folding on development of effective neutralizing antibodies during vaccination remains largely unexplored. In this study, we probed how mutational substitutions of streptococcal pyrogenic exotoxin A (SPEA), a model bacterial superantigen, affe...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 108(2003), 1 vom: 16. Juli, Seite 60-8
1. Verfasser: Carra, John H (VerfasserIn)
Weitere Verfasser: Welcher, Brent C, Schokman, Rowena D, David, Chella S, Bavari, Sina
Format: Aufsatz
Sprache:English
Veröffentlicht: 2003
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Bacterial Proteins Exotoxins Membrane Proteins SpeA protein, Streptococcus pyogenes Vaccines erythrogenic toxin