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01000caa a22002652 4500 |
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NLM126130981 |
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DE-627 |
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20250204040108.0 |
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tu |
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231222s2003 xx ||||| 00| ||chi c |
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|a pubmed25n0421.xml
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|a (DE-627)NLM126130981
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|a (NLM)12852806
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a chi
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| 100 |
1 |
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|a Hu, Sen
|e verfasserin
|4 aut
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|a A small dose of intraperitoneal injection of zymosan induces systemic inflammatory response and multiple organ dysfunction following gut ischemia-reperfusion injury
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|c 2003
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 11.12.2012
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|a Date Revised 10.07.2003
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To investigate the effects of a small dose of intraperitoneal injection of zymosan following gut ischemia-reperfusion injury on systemic inflammatory response and distant organ function
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|a METHODS: Wistar rats were randomly divided into three groups: gut ischemia-reperfusion injury (I-R) alone, intraperitoneal injection of zymosan (Z) alone, and gut ischemia-reperfusion followed by intraperitoneal injection of zymosan (M). Gut (I-R) was produced by occluding superior mesenteric artery for 60 minutes followed by gut reperfusion. A small dose(125 mg/kg) of zymosan was given intraperitoneally at 12 hours after recovery of gut blood flow
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|a RESULTS: Systemic inflammatory responses were found in all rats of three groups. The plasma level of tumor necrosis factor-alpha and activities of myeloperoxidase in lungs and intestines were significantly higher in animals in M group compared with those in I-R and Z groups. The incidence of multiple organ dysfunction syndrome (MODS) and mortality rate at 72 hours postinjury in two-hits group were significantly higher than those in I-R and Z group
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|a CONCLUSION: A small dose of intraperitoneal injection of zymosan could induce systemic inflammatory response and multiple organ dysfunction more readily when there is a precedent gut ischemia-reperfusion injury
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|a English Abstract
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Zymosan
|2 NLM
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| 650 |
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|a 9010-72-4
|2 NLM
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| 700 |
1 |
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|a Sheng, Zhi-yong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Jun-you
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Jiang-yang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jin, Hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lü, Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Xiao-guo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Rong
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 15(2003), 1 vom: 15. Jan., Seite 11-4
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
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|g volume:15
|g year:2003
|g number:1
|g day:15
|g month:01
|g pages:11-4
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