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NLM125993749 |
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DE-627 |
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tu |
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231222s2003 xx ||||| 00| ||chi c |
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|a pubmed25n0420.xml
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|a (DE-627)NLM125993749
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|a (NLM)12837191
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Shen, Hong
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Effect of oxidated low-density lipoprotein on early apoptosis of vascular smooth muscle cell
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| 264 |
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1 |
|c 2003
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 22.10.2012
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|a Date Revised 02.07.2003
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To investigate the apoptosis in vascular smooth muscle cell (VSMC) induced by oxidated low-density lipoprotein cholesterol (ox-LDL), and to discuss the relative mechanism of the apoptosis of VSMC
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|a METHODS: The growth index of VSMC of Wistar rat was determined. By using trypan blue to count sustaining cells, the proliferative effect of ox-LDL on culturing VSMC was observed. With flow cytometer, the apoptosis of VSMC induced by ox-LDL and the inhibitory effect of cyclooxygenase-2 (COX-2) inhibitor NS-398 on apoptosis were determined
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| 520 |
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|a RESULTS: After VSMC grew normally in culture, ox-LDL in concentrations of 35 mg/L and 50 mg/L could advance the growth period of VSMC to between 12 and 24 hours, and the proliferation of VSMC were obvious. The proliferation of VSMC induced by ox-LDL were inhibited by NS-398. The rate of apoptosis of VSMC in ox-LDL and NS-398 groups were higher than that of normal control
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|a CONCLUSION: ox-LDL could induce an obvious proliferation of VSMC in culture. Although NS-398 can decrease the proliferation of VSMC, it could enhance ox-LDL to induce apoptosis
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| 650 |
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|a English Abstract
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| 650 |
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4 |
|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Lipoproteins, LDL
|2 NLM
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| 650 |
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7 |
|a oxidized low density lipoprotein
|2 NLM
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| 700 |
1 |
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|a Yin, Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guo, Ji-hong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Tan-shi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Yun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Li-fang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 15(2003), 5 vom: 01. Mai, Seite 295-8
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
8 |
|g volume:15
|g year:2003
|g number:5
|g day:01
|g month:05
|g pages:295-8
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 15
|j 2003
|e 5
|b 01
|c 05
|h 295-8
|