Effect of genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production and renal disease in MRL/lpr mice

Effect of genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production and renal disease in MRL/lpr mice

Terminal deoxynucleotidyl transferase (TdT) places non-template-coded nucleotides (N additions) in the VH CDR3 of T cell receptors and immunoglobulins. Amino acids coded for by N additions are important in autoantibody binding of dsDNA in lupus. We hypothesized that a genetic lack of TdT would modul...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 107(2003), 3 vom: 15. Juni, Seite 186-97
1. Verfasser: Molano, Ivan D (VerfasserIn)
Weitere Verfasser: Redmond, Shakisha, Sekine, Hideharu, Zhang, Xian Kui, Reilly, Chris, Hutchison, Florence, Ruiz, Phil, Gilkeson, Gary S
Format: Aufsatz
Sprache:English
Veröffentlicht: 2003
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Antibodies Autoantibodies Biomarkers Immunoglobulin G DNA Nucleotidylexotransferase EC 2.7.7.31