Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice

Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice

Here we show that Janus kinase (JAK) 3 is an important molecular target for treatment of autoimmune insulin-dependent (type 1) diabetes mellitus. The rationally designed JAK3 inhibitor JANEX-1 exhibited potent immunomodulatory activity and delayed the onset of diabetes in the NOD mouse model of auto...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 106(2003), 3 vom: 01. März, Seite 213-25
1. Verfasser: Cetkovic-Cvrlje, Marina (VerfasserIn)
Weitere Verfasser: Dragt, Angela L, Vassilev, Alexei, Liu, Xing-Ping, Uckun, Fatih M
Format: Aufsatz
Sprache:English
Veröffentlicht: 2003
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Cytokines DNA-Binding Proteins Enzyme Inhibitors Interleukin-2 Milk Proteins Quinazolines STAT5 Transcription Factor Trans-Activators WHI P131 mehr... Tyrosine 42HK56048U Ovalbumin 9006-59-1 Protein-Tyrosine Kinases EC 2.7.10.1 JAK3 protein, human EC 2.7.10.2 Jak3 protein, mouse Janus Kinase 3