Characterization of antibody responses to endogenous and exogenous antigen in the nonobese diabetic mouse

Characterization of antibody responses to endogenous and exogenous antigen in the nonobese diabetic mouse

It is suggested that a T-helper cell 2 (Th2) shift and Th2 spreading of autoimmunity following immunization with beta-cell antigen causes diabetes protection. To address this, antibody titer and subclass to insulin, glutamic acid decarboxylase (GAD)65, IA-2, and IA-2beta proteins were measured by ra...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 106(2003), 2 vom: 01. Feb., Seite 155-62
1. Verfasser: Koczwara, Kerstin (VerfasserIn)
Weitere Verfasser: Schenker, Mike, Schmid, Sandra, Kredel, Katharina, Ziegler, Anette-Gabriele, Bonifacio, Ezio
Format: Aufsatz
Sprache:English
Veröffentlicht: 2003
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Comparative Study Journal Article Research Support, Non-U.S. Gov't Adjuvants, Immunologic Autoantibodies Autoantigens Diphtheria-Tetanus-Pertussis Vaccine ICA512 autoantibody Immunoglobulin G Insulin mehr... Isoenzymes Membrane Proteins Oleic Acids Recombinant Fusion Proteins mannide monooleate 25339-93-9 Mannitol 3OWL53L36A Aluminum Hydroxide 5QB0T2IUN0 Glucagon 9007-92-5 Methyltransferases EC 2.1.1.- Phosphatidylethanolamine N-Methyltransferase EC 2.1.1.17 PTPRN protein, human EC 3.1.3.48 PTPRN2 protein, human Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases Ptprn protein, mouse Receptor-Like Protein Tyrosine Phosphatases, Class 8 Glutamate Decarboxylase EC 4.1.1.15 glutamate decarboxylase 2